Mithramycin A
Chemical Name: (1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose
Purity: ≥95%
Biological Activity
Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury
J Shi, Y Bei, X Kong, X Liu, Z Lei, T Xu, H Wang, Q Xuan, P Chen, J Xu, L Che, H Liu, J Zhong, JP Sluijter, X Li, A Rosenzweig, J Xiao
Theranostics, 2017;7(3):664-676. -
TGF-beta-activated kinase 1 (TAK1) signaling regulates TGF-beta-induced WNT-5A expression in airway smooth muscle cells via Sp1 and beta-catenin.
Kumawat K, Menzen M, Slegtenhorst R, Halayko A, Schmidt M, Gosens R
PLoS ONE, 2014;9(4):e94801. -
Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion.
Demicheli and Garnier-Suillerot
Biochem.Biophys.Res.Commun., 1991;177:511 -
Mithramycin selectively inhibits transcription of G-C containing DNA.
Miller et al.
Am.J.Med.Sci., 1987;294:388 -
Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene.
Ray et al.
Am.J.Med.Sci., 1990;300:203
Product Datasheets
Citations for Mithramycin A
The citations listed below are publications that use Tocris products. Selected citations for Mithramycin A include:
6 Citations: Showing 1 - 6
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Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
Authors: Huang Et al.
Cell Res 2016;26:1112
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Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation.
Authors: Oh Et al.
J Neurosci 2015;6:e1750
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Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK.
Authors: Siddesha Et al.
J Cell Physiol 2014;229:845
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Prostaglandin E2 increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression.
Authors: Huang Et al.
FASEB J 2012;26:3703
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Role of SP-1 in SDS-induced adipose differentiation related protein synthesis in human keratinocytes.
Authors: Corsini Et al.
Gene Regul Syst Bio 2007;1:207
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The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF).
Authors: Duverger Et al.
Cell Death Dis 2004;90:2025
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