Mirin
Chemical Name: Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
Purity: ≥99%
Biological Activity
Mirin is a Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50 = 12 μM) and induces G2 cell cycle arrest. Also blocks homology-directed repair in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex.
Dupre et al.
Nat.Chem.Biol., 2008;4:119 -
Small molecule versus DNA repair mechanisms.
Stivers
Nat.Chem.Biol., 2008;4:86 -
Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex.
Garner et al.
Nat.Chem.Biol., 2009;5:129
Product Datasheets
Citations for Mirin
The citations listed below are publications that use Tocris products. Selected citations for Mirin include:
5 Citations: Showing 1 - 5
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Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.
Authors: Hollingworth Et al.
J Virol 2017;91
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Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs.
Authors: Berte Et al.
Mol Cancer Ther 2016;15:2665
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DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression
Authors: Hampp Et al.
Proc Natl Acad Sci U S A. 2016;113:E4311
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The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks.
Authors: Lee and Dunphy
Mol Biol Cell 2013;24:1343
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Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
Authors: Bothmer Et al.
Regul Pept 2013;210:115
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