Methylmalonate
Chemical Name: 2-Methylpropanedioic acid
Purity: ≥98%
Biological Activity
Methylmalonate is an intracellularly produced malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Experimental therapeutics in transgenic mouse models of Huntington's disease.
Beal and Ferrante
Nat.Rev.Neurosci., 2004;5:373 -
Methylmalonate toxicity in primary neuronal cultures.
McLaughlin et al.
Neuroscience, 1998;86:279 -
Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease.
Ehrlich
Neurotherapeutics, 2012;9:270
Product Datasheets
Citation for Methylmalonate
The citations listed below are publications that use Tocris products. Selected citations for Methylmalonate include:
1 Citation: Showing 1 - 1
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Psychotropic Drugs for the Management of Chronic Pain and Itch.
Authors: Belinskaia Et al.
Pharmaceuticals (Basel) 2019;12
FAQs
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