Mesulergine hydrochloride
Chemical Name: N'-[(8-α1,6-dimethylergolin-8-yl]-N,N-dimethylsulfamide hydrochloride
Purity: ≥99%
Biological Activity
Mesulergine hydrochloride is a 5-HT2A and 2C receptor antagonist (pA2 values are 9.1 for each receptor) and D2-like dopamine receptor partial agonist (Ki = 8 nM). Displays antiprolactin and antiparkinsonian effects in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
Hoyer et al.
Pharmacol.Rev., 1994;46:157 -
DA agonistic potency of two novel prolactin release-inhibiting ergolines.
Marko
Eur.J.Pharmacol., 1984;101:263 -
Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D1- and D2-receptors.
Markstei
Eur.J.Pharmacol., 1983;95:101
Product Datasheets
Citations for Mesulergine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Mesulergine hydrochloride include:
2 Citations: Showing 1 - 2
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Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers.
Authors: Moutkine Et al.
J Biol Chem 2017;292:6352
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Ergot Alkaloids (Re)generate New Leads as Antiparasitics.
Authors: Chan Et al.
Neurotoxicology 2015;9:e0004063
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