MeBIO
Chemical Name: (2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime
Purity: ≥99%
Biological Activity
MeBIO is a control analog of 6-bromoindirubin-3'-oxime (BIO). Displays minimal activity against CDK1/Cyclin B, GSK-3 α/β, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 μM respectively). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.Active Analog also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Prostaglandin E2 promotes survival of naive UCB T cells via the Wnt/beta-catenin pathway and alters immune reconstitution after UCBT.
Li L, Kim H, Nellore A, Patsoukis N, Petkova V, McDonough S, Politikos I, Nikiforow S, Soiffer R, Antin J, Ballen K, Cutler C, Ritz J, Boussiotis V
Blood Cancer J, 2014;4(0):e178. -
GSK-3-selective inhibitors derived from tyrian purple indirubins.
Meijer et al.
Chem.Biol., 2003;10:1255 -
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Polychronopoulos et al.
J.Med.Chem., 2004;47:935 -
Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins.
Knockaert et al.
Oncogene, 2004;23:4400
Product Datasheets
Citations for MeBIO
The citations listed below are publications that use Tocris products. Selected citations for MeBIO include:
2 Citations: Showing 1 - 2
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Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages.
Authors: Volpini Et al.
Front Immunol 2018;9:859
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TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.
Authors: Diamantopoulou Et al.
Cancer Cell 2017;31:621
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