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MDL 100907

Catalog #: 4173
11 Citations Datasheet
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4173/10
4173/50
MDL 100907 | CAS No. 139290-65-6 | 5-HT2A Receptor Antagonists
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Description: Potent and selective 5-HT2A antagonist
Alternative Names: Volinanserin

Chemical Name: (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol

Purity: ≥98%

Product Details
Citations (11)
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Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

MDL 100907 is a potent and selective 5-HT2A receptor antagonist (Ki = 0.36 nM, IC50 = 3.3-5.1 nM). MDL 100907 exhibits > 80-fold selectivity for 5-HT2A receptors over other serotonergic receptor subtypes. MDL 100907 is neuroprotective; protects cultured dopaminergic neurons from MPP+ induced toxicity. Antipsychotic agent in vivo.

Technical Data

M.Wt:
373.46
Formula:
C22H28FNO3
Solubility:
Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
139290-65-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for MDL 100907

The citations listed below are publications that use Tocris products. Selected citations for MDL 100907 include:

11 Citations: Showing 1 - 10

  1. Targeting 5-HT2A receptors and Kv7 channels in PFC to attenuate chronic neuropathic pain in rats using a spared nerve injury model.
    Authors: Kara R Et al.
    Neurosci Lett  2022;789:136864
  2. Pimavanserin, a 5HT 2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer's disease.
    Authors: Yuede Et al.
    J.Neurochem.  2021;156:658
  3. Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability.
    Authors: Rui Et al.
    Elife  2021;10
  4. A neural circuit for comorbid depressive symptoms in chronic pain.
    Authors: Zhou Et al.
    Nat Neurosci  2019;22:1649
  5. Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells.
    Authors: Alharris Et al.
    Oncotarget  2019;10:45
  6. A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory.
    Authors: Andrew Et al.
    Neuron  2019;103:489-505.e7
  7. Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.
    Authors: Athilingam Et al.
    Elife  2017;6
  8. Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers.
    Authors: Moutkine Et al.
    J Biol Chem  2017;292:6352
  9. Sleep Homeostatic and Waking Behavioral Phenotypes in Egr3-Deficient Mice Associated with Serotonin Receptor 5-HT2 Deficits.
    Authors: Grønli Et al.
    Sleep  2016;39:2189
  10. Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
    Authors: Bocchio Et al.
    Neuropsychopharmacology  2015;40:3015

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