LY 2603618
Chemical Name: N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy)phenyl]-N'-(5-methyl-2-pyrazinyl)urea
Purity: ≥98%
Biological Activity
LY 2603618 is a potent and selective Chk1 inhibitor (IC50 = 7 nM). Inhibits Chk1 autophosphorylation. Induces cell cycle arrest in the G2/M phase and induces the DNA damage response in lung cancer cells. Inhibits growth of NSCLC xenografts in mice when administered in combination with Pemetrexed (Cat.No. 6185).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells.
Wang et al.
Apoptosis, 2014;19:1389 -
Preclinical analyses and phase I evaluation of LY2603618 administered in combination with pemet. and cisp. in patients with advanced cancer.
Calvo et al.
Invest.New Drugs, 2014;32:955
Product Datasheets
Citation for LY 2603618
The citations listed below are publications that use Tocris products. Selected citations for LY 2603618 include:
1 Citation: Showing 1 - 1
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Inhibition of Chk2 promotes neuroprotection, axon regeneration, and functional recovery after CNS injury.
Authors: Adam M Et al.
Sci Adv 2022;8:eabq2611
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