Luteolin

Biological Activity

Luteolin is an anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activation. Also inhibits TNF-α -induced COX-2 expression. Antiproliferative and chemopreventative; inhibits proliferation of Lewis lung carcinoma cells in vivo. Inhibits influenza virus replication in vitro by preventing viral entry. Molecular docking studies also indicate binding to SARS-CoV-2 main protease (M^pro or 3CL^pro).

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. A critical role of luteolin-induced reactive oxygen species in blockage of tumour necrosis factor-activated nuclear factor-κB pathway and sensitization of apoptosis in lung cancer cells.
   Ju et al.
   Mol.Pharmacol., 2007;71:1381
2. Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophage.
   Chen et al.
   Life Sci., 2007;81:1602
3. Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression.
   Yan et al.
   J.Nat.Med., 2019;73:487
4. Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking.
   Yu et al.
   Int.J.Antimicrob.Agents, 2020;

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