LU AA33810

Catalog #: 3562 Datasheet

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LU AA33810 | CAS No. 304008-29-5 | NPY Receptor Antagonists

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Description: Potent NPY Y5 receptor antagonist

Chemical Name: N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide

Purity: ≥98%

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Biological Activity

LU AA33810 is a potent neuropeptide Y (NPY) Y₅ receptor antagonist (K_i = 1.5 nM in vitro). Displays ≥ 3300-fold affinity for Y₅ over Y₁, Y₂ and Y₄ receptors. Also binds human 5-HT_2B and 5-HT_1A receptors (K_i values are 247 and 478 nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.

Technical Data

M.Wt:

423.62

Formula:

C₁₉H₂₅N₃O₂S₃

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

304008-29-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects
Walker et al.
J.Pharmacol.Exp.Ther., 2009;328:900

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