LTURM 34

Catalog #: 5834 Datasheet

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5834/10

LTURM 34 | CAS No. 1879887-96-3 | DNA-dependent Protein Kinase Inhibitors

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Description: Potent DNA-PK inhibitor; also increases CRISPR-Cas9 deletion efficiency

Chemical Name: 8-(4-Dibenzothienyll)-2-(4-morpholinyl)-4H-1,3-benzoxazin-4-one

Purity: ≥98%

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

LTURM 34 is a potent DNA-PK inhibitor (IC₅₀ = 34 nM). Exhibits 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell lines in vitro. LTURM 34 also increases CRISPR-Cas9 deletion efficiency.

Technical Data

M.Wt:

414.48

Formula:

C₂₄H₁₈N₂O₃S

Solubility:

Soluble to 50 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

1879887-96-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines.
Morrison et al.
Eur.J.Med.Chem., 2016;110:326

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