LNT 1
Chemical Name: 1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
Purity: ≥98%
Biological Activity
LNT 1 is a potent flap endonuclease 1 (FEN1) inhibitor (IC50 = 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cells in vitro; induces DNA damage response.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.
Ward TA, McHugh PJ, Durant ST.
PLoS ONE. -
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site.
Exell et al.
Nat.Chem.Bio., 2016;12:815
Product Datasheets
Citation for LNT 1
The citations listed below are publications that use Tocris products. Selected citations for LNT 1 include:
1 Citation: Showing 1 - 1
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NAD+ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells.
Authors: Mai Et al.
NAR Cancer 2021;3:zcab044
FAQs
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