Home / Additional Retinoic Acid Receptor Compounds / Liarozole dihydrochloride

Liarozole dihydrochloride

Catalog #: 2705
3 Citations Datasheet
Catalog # Availability Size / Price Qty
2705/10
2705/50
Liarozole dihydrochloride | CAS No. 1883548-96-6 | Additional Retinoic Acid Receptor Compounds
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Description: Blocks retinoic acid metabolism
Alternative Names: R-75251

Chemical Name: 5-[(3-Chlorophenyl)-1H-imidazol-1-ylmethyl]-1H-benzimidazole dihydrochloride

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Liarozole dihydrochloride is a cytochrome P450 inhibitor. Inhibits several cytochrome P450 enzymes including aromatase (CYP19) and retinoic acid 4-hydroxylase (CYP26). Blocks retinoic acid metabolism (retinoic acid metabolism blocking agent, RAMBA). Displays antitumor activity against androgen-dependent and independent rat prostate carcinomas.

Technical Data

M.Wt:
381.69
Formula:
C17H13ClN4.2HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in water
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1883548-96-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Liarozole dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Liarozole dihydrochloride include:

3 Citations: Showing 1 - 3

  1. Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model.
    Authors: Bunt Et al.
    Islets  2016;8:83
  2. Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell- Mediated Immunity in Colorectal Cancer
    Authors: Bhattacharya Et al.
    Immunity  2016;45:1
  3. Retinoic acid regulation by CYP26 in vertebrate lens regeneration.
    Authors: Thomas and Henry
    Neuropsychopharmacology  2014;386:291

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