Levetiracetam

Biological Activity

Levetiracetam is an antiepileptic that displays distinctive properties from conventional antiepileptic drugs. Displays potent seizure protection in animal models of chronic epilepsy but lacks activity in acute seizure models. Binds synaptic vesicle protein 2A (SV2A) and inhibits Na⁺-dependent Cl^-/HCO₃^- exchange. In a mouse model of Alzheimer's disease, Levetiracetam rescues levels of presynaptic vesicle fusion and neurotransmitter release, reduces Aβ42 and APP levels and decreases deposits of amyloid plaque; in vitro Levetiracetam inhibits Aβ-induced glutamate from astrocytes.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. LeveT: the profile of a novel anticonvulsant drug - part I: preclinical data.
   Smedt et al.
   CNS Drug Rev., 2007;13:43
2. Effect of LeveT on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl₃ injection.
   Ueda et al.
   Brain Res., 2007;1151:55

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