LCL 161, phenol

Biological Activity

LCL 161, phenol is a functionalized IAP (XIAP and cIAP) ligand for PROTAC^® research and development. Boc protected LCL 161. Supplied with a phenol functional handle for ready conjugation to a linker/target protein ligand. NanoBRET assays show EC₅₀ values of 7.5, 18.2 and 25.3 nM for cIAP1, XIAP and cIAP2 proteins, respectively. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. In vivo knockdown of pathogenic proteins via specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs).
   Ohoka et al.
   J.Biol.Chem., 2017;292:4556
2. Targeting the allosteric site of oncoprotein BCR-ABL as an alternative strategy for effective target protein degradation.
   Shimokawa et al.
   ACS Med.Chem.Lett., 2017;8:1042

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