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Latrunculin A

Catalog #: 3973
32 Citations Datasheet
Catalog # Availability Size / Price Qty
3973/100U
Latrunculin A | CAS No. 76343-93-6 | Actin-related Products
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Description: Inhibitor of actin assembly and polymerization

Chemical Name: 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone

Purity: ≥95%

Product Details
Citations (32)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Latrunculin A is a reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.

This product is typically reconstituted in DMSO as a primary solvent.

Technical Data

M.Wt:
421.55
Formula:
C22H31NO5S
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
76343-93-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Endophilin marks and controls a clathrin-independent endocytic pathway.
    Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H
    Nature, 2015;517(7535):460-5.
  2. Actin-latrunculin A structure and function.
    Yarmola et al.
    J.Biol.Chem., 2000;275:28120
  3. Latrunculin alters the actin-monomer subunit interface to prevent polymerization.
    Morton et al.
    Nat.Cell Biol., 2000;2:376
  4. On the chemistry of latrunculins A and B.
    Blasberger et al.
    Liebigs.Ann.Chem., 1989;1989:1171

Product Datasheets

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Citations for Latrunculin A

The citations listed below are publications that use Tocris products. Selected citations for Latrunculin A include:

32 Citations: Showing 1 - 10

  1. Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters.
    Authors: Jacob Et al.
    EMBO J  2023;42:e112030
  2. Cortical softening elicits zygotic contractility during mouse preimplantation development.
    Authors: Andrew G Et al.
    PLoS Biol  2022;20:e3001593
  3. A novel Fiji/ImageJ plugin for the rapid analysis of blebbing cells.
    Authors: Sandrine B Et al.
    PLoS One  2022;17:e0267740
  4. Axon terminals control endolysosome diffusion to support synaptic remodelling.
    Authors: Artur Et al.
    Life Sci Alliance  2021;4
  5. Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles.
    Authors: Richard A Et al.
    Neuron  2021;109:938-946.e5
  6. ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells.
    Authors: Maria F Et al.
    Elife  2021;10
  7. Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice.
    Authors: Se-Young Et al.
    Mol Cells  2020;43:360-372
  8. Regulation of Collective Metastasis by Nanolumenal Signaling.
    Authors: Yin Et al.
    Cell  2020;183:395-410.e19
  9. Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells.
    Authors: Santiago Et al.
    Cancers (Basel)  2020;12
  10. A spike-timing-dependent plasticity rule for dendritic spines.
    Authors: Tazerart Et al.
    Nat Commun  2020;11:4276
  11. RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance.
    Authors: Lionarons Et al.
    Cancer Cell  2019;36:68
  12. A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport.
    Authors: Zheng Et al.
    Cell Rep  2019;28:3224-3237.e5
  13. Identification of the kinase STK25 as an upstream activator of LATS signaling.
    Authors: Lim Et al.
    Nat Commun  2019;10:1547
  14. Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments.
    Authors: Wisdom Et al.
    Nat Commun  2018;9:4144
  15. Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity.
    Authors: Davies Et al.
    Elife  2018;7
  16. Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation.
    Authors: Neumann Et al.
    Dev Cell  2018;45:67
  17. Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells.
    Authors: Lettau Et al.
    Int Immunol  2018;30:215
  18. The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.
    Authors: Haag Et al.
    Cell Rep  2018;24:2418
  19. Visualization of Membrane Pore in Live Cells Reveals a Dynamic-Pore Theory Governing Fusion and Endocytosis.
    Authors: Hsueh-Cheng Et al.
    Cell  2018;173:934-945.e12
  20. Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock.
    Authors: Hubaud Et al.
    Cell  2017;171:668
  21. Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
    Authors: Oenema Et al.
    Oncotarget  2016;8:e65580
  22. The role of Rab6a and phosphorylation of non-muscle myosin IIA tailpiece in alcohol-induced Golgi disorganization.
    Authors: Petrosyan Et al.
    Sci Rep  2016;6:31962
  23. Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction.
    Authors: Koopmans Et al.
    Sci Rep  2016;6:30676
  24. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation
    Authors: Han Et al.
    Nature  2016;539:570
  25. Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
    Authors: Araki Et al.
    PLoS One  2015;85:173
  26. Spatiotemporal quantification of subcellular ATP levels in a single HeLa cell during changes in morphology.
    Authors: Suzuki Et al.
    Neuron  2015;5:16874
  27. Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication.
    Authors: Saba Et al.
    Am J Respir Cell Mol Biol  2014;50:974
  28. Recycling endosomes undergo rapid closure of a fusion pore on exocytosis in neuronal dendrites.
    Authors: Daniel Et al.
    J Neurosci  2014;34:11106-18
  29. Arhgef7 promotes activation of the Hippo pathway core kinase Lats.
    Authors: Arash Et al.
    EMBO J  2014;33:2997
  30. Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte.
    Authors: Dalton and Carroll
    J Cell Sci  2013;126:2955
  31. Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.
    Authors: Kawashima Et al.
    Chem Biol  2012;19:893
  32. Dopamine D4 receptors regulate AMPA receptor trafficking and glutamatergic transmission in GABAergic interneurons of prefrontal cortex.
    Authors: Zhen Et al.
    J Neurosci  2009;29:550-62

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