L-NAME hydrochloride
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Description: Non-selective NOS inhibitor
Chemical Name: NG-Nitro-L-arginine methyl ester hydrochloride
Biological Activity
L-NAME hydrochloride is a NO synthase inhibitor.Technical Data
M.Wt:
269.69
Formula:
C7H15N5O4.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Store at RT
CAS No:
51298-62-5
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Nutritional state-dependent ghrelin activation of vasopressin neurons via retrograde trans-neuronal-glial stimulation of excitatory GABA circuits.
Haam J, Halmos K, Di S, Tasker J
J Neurosci, 2014;34(18):6201-13. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype
Nat Immunol, 2016;0(0):. -
Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system?
Moore and Handy
TiPS, 1997;18:204 -
Nitric oxide synthases in mammals.
Knowles et al.
Biochem.J., 1994;298:249 -
Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement for bioactivation to the free acid, NG-nitro-L-arginine.
Pfeiffer et al.
Br.J.Pharmacol., 1996;118:1433
Product Datasheets
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Citations for L-NAME hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for L-NAME hydrochloride include:
20 Citations: Showing 1 - 10
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Structural and pharmacological basis for the induction of mitochondrial biogenesis by formo. but not clenbu.
Authors: Cameron
Sci Rep 2017;7(1):10578
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Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
Authors: Cramer Et al.
Proc Natl Acad Sci U S A 2015;35:5664
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Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis.
Authors: Bucher Et al.
J Cereb Blood Flow Metab 2014;34:1128
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NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size.
Authors: Bice Et al.
Cardiovasc Res 2014;101:220
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Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism.
Authors: Elks Et al.
PLoS Pathog 2013;9:e1003789
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Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.
Authors: Orru Et al.
Neuropharmacology 2013;67:476
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Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts.
Authors: Gross Et al.
J Mol Cell Cardiol 2013;59:20
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Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4.
Authors: Townsend and Emala
Am J Physiol Lung Cell Mol Physiol 2013;305:L396
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Antioxidant Functions of Nitric Oxide Synthase in a Methicillin Sensitive Staphylococcus aureus.
Authors: Vaish and Singh
Br J Cancer 2013;2013:312146
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Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase.
Authors: Gallo and Iadecola
J Neurosci 2011;31:6947
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Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS.
Authors: Dai Et al.
Am J Physiol Heart Circ Physiol 2011;301:H1248
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Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i
Authors: Sunters Et al.
J Biol Chem 2010;285:8743
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Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
Authors: Huang and Hsu
Cereb Cortex 2010;20:982
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Detection of EETs and HETE-generating cytochrome P-450 enzymes and the effects of their metabolites on myometrial and vascular function.
Authors: Pearson Et al.
Am J Physiol Endocrinol Metab 2009;297:E647
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Hydroxyurea generates nitric oxide in human erythroid cells: mechanisms for gamma-globin gene activation.
Authors: Lou Et al.
Exp Biol Med (Maywood) 2009;234:1374
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TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
Authors: Gibson Et al.
Neuron 2008;57:746
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Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro.
Authors: Silva Et al.
Br J Pharmacol 2007;151:195
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Endocannabinoids control the induction of cerebellar LTD.
Authors: Safo and Regehr
Neuron 2005;48:647
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Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pa
Authors: Chen Et al.
J Virol 2002;76:9407
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Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse.
Authors: Casado Et al.
Int J Microbiol 2000;97:11593
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