L-Buthionine sulfoximine
Chemical Name: (2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Purity: ≥98%
Biological Activity
L-Buthionine sulfoximine is an irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; depletes glutathione levels by inhibiting synthesis. Induces ferroptosis in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Regulation of ferroptotic cancer cell death by GPX4.
Yang et al.
Cell, 2014;156:317 -
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)
Griffith & Meister
J.Biol.Chem., 1979;254:7558 -
Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.
Griffith et al.
J.Biol.Chem., 1982;257:13704
Product Datasheets
Citation for L-Buthionine sulfoximine
The citations listed below are publications that use Tocris products. Selected citations for L-Buthionine sulfoximine include:
1 Citation: Showing 1 - 1
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Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets.
Authors: Gregory H Et al.
Cell Rep 2021;37:110037
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