L-Azidonorleucine hydrochloride

Biological Activity

L-Azidonorleucine hydrochloride is an unnatural amino acid; methionine surrogate. Can be incorporated into proteins by a mutant methionyl tRNA synthetase to enable cell-type specific analysis of protein synthesis. For use with bio-orthogonal non-canonical amino-acid tagging (BONCAT) or fluorescent non-canonical amino acid tagging (FUNCAT). Labeling does not affect the normal localization of the labeled proteins.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Cell-type-specific metabolic labeling of nascent proteomes in vivo.
   Alvarez-Castelao et al.
   Nat.Biotechnol., 2017;35:1196
2. Engineered aminoacyl-tRNA synthetase for cell-selective analysis of mammalian protein synthesis.
   Mahdavi et al.
   J.Am.Chem.Soc., 2016;138:4278

Product Datasheets