L-AP5

Biological Activity

D-isomer, DL mixture and sodium salt also available.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Critical role of calcitonin gene-related peptide receptors in cortical spreading depression.
   Tozzi A, de Iure A, Di Filippo M, Costa C, Caproni S, Pisani A, Bonsi P, Picconi B, Cupini L, Materazzi S, Geppetti P, Sarchielli P, Calabresi P
   Proc Natl Acad Sci U S A, 2012;109(46):18985-90.
2. The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
   Evans et al.
   Br.J.Pharmacol., 1982;75:65
3. Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord.
   Davies and Watkins
   Brain Res., 1982;235:378
4. Utilization of the resolved L-isomer fo 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
   Schulte et al.
   Brain Res., 1994;649:203

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