L-741,626
Chemical Name: 3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole
Purity: ≥98%
Biological Activity
L-741,626 is a potent D2 dopamine receptor selective antagonist, with affinities of 2.4, 100 and 220 nM for D2, D3 and D4 receptors respectively. Centrally active following systemic administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Treatment with the antipsychotic agent, risperidone, reduces disease severity in experimental autoimmune encephalomyelitis.
O'Sullivan D, Green L, Stone S, Zareie P, Kharkrang M, Fong D, Connor B, La Flamme A
PLoS ONE, 2014;9(8):e104430. -
Antagonism of the effects of (+)-PD 128907 on midbrain DA neurones in rat brain slices by a selective D2 receptor antagonist L-741,626.
Bowery et al.
Br.J.Pharmacol., 1996;119:1491 -
3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: an antagonist with high affinity and selectivity for the human DA D4 receptor.
Kulagowski et al.
J.Med.Chem., 1996;39:1941 -
S33084, a novel, potent, selective, and competitive antagonist at DA D3-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626.
Millan et al.
J.Pharmacol.Exp.Ther., 2000;293:1063 -
Human D2 and D4 DA receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respect
Pillai et al.
Neuropharmacology, 1998;37:983
Product Datasheets
Citations for L-741,626
The citations listed below are publications that use Tocris products. Selected citations for L-741,626 include:
10 Citations: Showing 1 - 10
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Functional roles of ST8SIA3-mediated sialylation of striatal DA D2 and adenosine A2A receptors.
Authors: Lin Et al.
Transl Psychiatry 2019;9:209
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GPR139 and DA D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact.
Authors: Wang Et al.
Front Neurosci 2019;13:281
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Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation.
Authors: Zhang Et al.
Neuron 2018;98:918
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Biased OXTergic Modulation of Midbrain DA Systems.
Authors: Xiao Et al.
Neuron 2017;95:368
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Examining the Effects of Sodium Ions on the Binding of Antagonists to DA D 2 and D 3 Receptors
Authors: Newton Et al.
PLoS One 2016;11:e0158808
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A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation.
Authors: Wang Et al.
J Neurosci 2015;11:2057
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DA receptors in human embryonic stem cell neurodifferentiation.
Authors: Belinsky Et al.
Stem Cells Dev 2013;22:1522
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Leptin reduces food intake via a DA D2 receptor-dependent mechanism.
Authors: Billes Et al.
Mol Metab 2012;1:86
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Olfactory modulation by DA in the context of aversive learning.
Authors: Dacks Et al.
J Neurophysiol 2012;108:539
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Inhibition of ATP-sensitive potassium channels by halope.
Authors: Yang Et al.
Br J Pharmacol 2004;143:960
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