L-690,330
Chemical Name: [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
Biological Activity
L-690,330 is a potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Chemical modulators of autophagy as biological probes and potential therapeutics.
Fleming et al.
Nat.Chem.Biol., 2011;7:9 -
Li induces autophagy by inhibiting inositol monophosphatase.
Sarkar et al.
J.Cell.Biol., 2005;170:1101 -
In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330.
Atack et al.
J.Neurochem., 1993;60:652 -
Effects of L-690,488, a pro-drug of the bisphosphonate inisotol monophosphatase inhibitor L-690,330, on phosphatidylinisotol cycle markers.
Atack et al.
J.Pharmacol.Exp.Ther., 1994;270:70
Product Datasheets
Citations for L-690,330
The citations listed below are publications that use Tocris products. Selected citations for L-690,330 include:
6 Citations: Showing 1 - 6
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LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1.
Authors: Harding Et al.
Infect Immun 2013;81:4261
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Inhibition of inositol monophosphatase by Li chloride induces selective macrophage apoptosis in atherosclerotic plaques.
Authors: Meyer Et al.
Br J Pharmacol 2011;162:1410
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A rational mechanism for combination treatment of Huntington's disease using Li and rapamycin.
Authors: Sarkar Et al.
J Cell Biol 2008;17:170
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Regulation of autophagy by the inositol trisphosphate receptor.
Authors: Criollo Et al.
Cell Death Differ 2007;14:1029
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Li induces autophagy by inhibiting inositol monophosphatase.
Authors: Sarkar Et al.
Infect Immun 2005;170:1101
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Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity.
Authors: Westfall Et al.
J Cell Biol 2003;162:889
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