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KT 182

Catalog #: 6738 Datasheet
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6738/10
KT 182 | CAS No. 1402612-62-7 | Hydrolase Inhibitors
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Description: Potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor

Chemical Name: [4-[3'-(Hydroxymethyl)[1,1'-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)methanone

Purity: ≥98%

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Biological Activity

KT 182 is a potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 1.7 nM). KT 182 exhibits selectively for ABHD6 over other brain and liver serine hydrolases, but does exhibit some activity at carboxylesterase-1. KT 182 inhibits ABHD6 activity in the brain and liver in mice following intraperitoneal administration.

Technical Data

M.Wt:
438.53
Formula:
C27H26N4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1402612-62-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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