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KIN001-266

Catalog #: 6984 Datasheet
Catalog # Availability Size / Price Qty
6984/2
KIN001-266 | CAS No. 915363-56-3 | MAP3K8/Tpl2/COT
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Description: Potent and selective Tpl2 (MAP3K8) inhibitor

Chemical Name: 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-quinolinecarbonitrile

Purity: ≥98%

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Biological Activity

KIN001-266 is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 1.6 nM). It exhibits 6875-fold selectivity over EGFR. In vivo, it inhibits TNF-α production in a LPS-stimulated rat inflammation model. KIN001-266 is orally bioavailable.

Technical Data

M.Wt:
539.44
Formula:
C26H25Cl2FN8
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
915363-56-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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