Kifunensine

Biological Activity

Kifunensine is an inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Kifunensine inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with K_i values of 130 and 23 nM respectively. Kifunensine disrupts normal trafficking of the GLUT1 transporter, leading to decreased glucose uptake in human renal epithelial cells. Kifunensine impaires tumour cell aggregation in human ovarian cancer cells in vitro.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein
   HT Nguyen, N Madani, H Ding, E Elder, A Princiotto, C Gu, P Darby, J Alin, A Herschhorn, JC Kappes, Y Mao, JG Sodroski
   Virol. J, 2017;14(1):33.
2. A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I.
   Hering et al.
   J.Org.Chem., 2005;70:9892
3. Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I.
   Elbein et al.
   J.Biol.Chem., 1990;265:1559

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