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JZP 430

Catalog #: 5844 Datasheet
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5844/10
5844/50
JZP 430 | CAS No. 1672691-74-5 | Hydrolase Inhibitors
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Description: Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor

Chemical Name: 4-(4-Morpholinyl)-1,2,5-thiadiazol-3-yl N-cyclooctyl-N-methylcarbamate

Purity: ≥98%

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Biological Activity

JZP 430 is a potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 44 nM). Exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).

Technical Data

M.Wt:
354.47
Formula:
C16H26N4O3S
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1672691-74-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.
    Patel et al.
    Chem.Med.Chem., 2015;10:253

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