JW 480

Catalog #: 4327 Datasheet

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4327/50

JW 480 | CAS No. 1354359-53-7 | Hydrolase Inhibitors

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Description: Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)

Chemical Name: 2-Isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate

Purity: ≥98%

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Product Details

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Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

JW 480 is a potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (neutral cholesterol ester hydrolase 1 or NCEH1) (IC₅₀ = 20 nM in mouse brain). JW 480 impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo and reduces monoalkylglycerol ether (MAGE) levels.

Technical Data

M.Wt:

333.42

Formula:

C₂₂H₂₃NO₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1354359-53-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold under license from The Scripps Research Institute.

Product Datasheets

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