Home / P2X Receptor Antagonists / JNJ 47965567

JNJ 47965567

Catalog #: 5299
4 Citations Datasheet
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5299/10
5299/50
JNJ 47965567 | CAS No. 1428327-31-4 | P2X Receptor Antagonists
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Description: Potent and selective P2X7 antagonist; brain penetrant

Chemical Name: 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

JNJ 47965567 is a potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. Reduces BzATP-induced IL-1β release from monocytes in vitro and from rat brain in vivo. Attenuates amphetamine-induced hyperactivity in rats. Brain penetrant.

Technical Data

M.Wt:
488.64
Formula:
C28H32N4O2S
Solubility:
Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1428327-31-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for JNJ 47965567

The citations listed below are publications that use Tocris products. Selected citations for JNJ 47965567 include:

4 Citations: Showing 1 - 4

  1. Detection and Functional Evaluation of the P2X7 Receptor in hiPSC Derived Neurons and Microglia-Like Cells.
    Authors: Andras Et al.
    Front Mol Neurosci  2022;14:793769
  2. Autocrine regulation of wound healing by ATP release and P2Y 2 receptor activation
    Authors: McEwan Et al.
    Life Sci  2021;283:119850
  3. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.
    Authors: Uderhardt Et al.
    Cell  2019;177:541
  4. Microglial glutamate release evoked by α-synuclein aggregates is prevented by dopamine.
    Authors: Rita Et al.
    Glia  2018;66:2353-2365

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