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Jasplakinolide

Catalog #: 2792
10 Citations Datasheet
Catalog # Availability Size / Price Qty
2792/100U
Jasplakinolide | CAS No. 102396-24-7 | Actin-related Products
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Description: Stabilizes F-actin; promotes actin polymerization

Chemical Name: Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]

Purity: ≥97%

Product Details
Citations (10)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Jasplakinolide rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.

Technical Data

M.Wt:
709.67
Formula:
C36H45BrN4O6
Solubility:
Soluble to 2 mg/ml in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
102396-24-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. PKC? links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton
    GJ Britton, R Ambler, DJ Clark, EV Hill, HM Tunbridge, KE McNally, BR Burton, P Butterweck, C Sabatos-Pe, LA Hampton-O', P Verkade, C Wlfing, DC Wraith
    Elife, 2017;6(0):.
  2. Endophilin marks and controls a clathrin-independent endocytic pathway.
    Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H
    Nature, 2015;517(7535):460-5.
  3. Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP
    B Zhu, C Rippe, J Holmberg, S Zeng, L Perisic, S Albinsson, U Hedin, B Uvelius, K Swärd
    Sci Rep, 2018;8(1):13025.
  4. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin.
    Bubb et al.
    J.Biol.Chem., 1995;269:14869
  5. Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide.
    Cramer
    Curr.Biol., 1999;9:1095
  6. Effects of jasplakinolide on the kinetics of actin polymerization.
    Bubb et al.
    J.Biol.Chem., 2000;275:5163

Product Datasheets

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Citations for Jasplakinolide

The citations listed below are publications that use Tocris products. Selected citations for Jasplakinolide include:

10 Citations: Showing 1 - 10

  1. Evaluation of Machine Learning Classifiers to Predict Compound Mechanism of Action When Transferred across Distinct Cell Lines.
    Authors: Warchal Et al.
    SLAS Discov  2019;24:224
  2. Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy.
    Authors: Pfitzer Et al.
    Cell Death Dis  2019;10:302
  3. Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP.
    Authors: Zhu Et al.
    Sci Rep  2018;8:13025
  4. Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation.
    Authors: Neumann Et al.
    Dev Cell  2018;45:67
  5. CD47 surface stability is sensitive to actin disruption prior to inclusion within the band 3 macrocomplex.
    Authors: Mordue Et al.
    Sci Rep  2017;7:2246
  6. Activation of α7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats.
    Authors: Galvez Et al.
    Neuropharmacology  2016;105:378
  7. Regulation of smooth muscle dystrophin and synaptopodin 2 expression by actin polymerization and vascular injury.
    Authors: Turczynska Et al.
    Cell  2015;35:1489
  8. Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.
    Authors: Ruprecht Et al.
    PLoS One  2015;160:673
  9. Differential Support of Aspergillus fumigatus Morphogenesis by Yeast and Human Actins.
    Authors: LeClaire and Fortwendel
    PLoS One  2015;10:e0142535
  10. Myocardin Family Members Drive Formation of Caveolae.
    Authors: Krawczyk Et al.
    PLoS One  2015;10:e0133931

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