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IWP L6

Catalog #: 4992 Datasheet
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4992/10
4992/50
IWP L6 | CAS No. 1427782-89-5 | PORCN Inhibitors
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Description: Potent PORCN inhibitor

Chemical Name: N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide

Purity: ≥98%

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

IWP L6 is a potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM). Shown to inhibit Wnt-dependent processes such as tailfin regeneration and posterior axis formation in zebrafish; also reduces branching morphogenesis in cultured mouse embryonic kidneys.

Technical Data

M.Wt:
472.58
Formula:
C25H20N4O2S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1427782-89-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The development of highly potent inhibitors for Porcupine.
    Wang et al.
    J.Med.Chem., 2013;56:2700

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