IWP 12

Catalog #: 5279 Datasheet

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IWP 12 | CAS No. 688353-45-9 | PORCN Inhibitors

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Description: Potent PORCN inhibitor; active in vivo

Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]acetamide

Purity: ≥98%

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

IWP 12 is a potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC₅₀ = 15 nM). Inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Blocks zebrafish tailfin regeneration in vivo.

Technical Data

M.Wt:

418.56

Formula:

C₁₈H₁₈N₄O₂S₃

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

688353-45-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine.
Dodge et al.
J.Biol.Chem., 2012;287:23246

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