Isradipine

Catalog #: 2004
6 Citations Datasheet

Catalog #	Availability	Size / Price	Qty
2004/10
2004/50

Isradipine | CAS No. 75695-93-1 | Cav1.x Channel Blockers

1 Image

Description: CaV1.x blocker

Alternative Names: PN 200-110

Chemical Name: 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester

Purity: ≥98%

View All Products for Cav1.x Channel Blockers

Product Details

Citations (6)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Isradipine is a potent and selective L-type voltage-gated Ca²⁺ channel blocker. EC₅₀ and pA₂ values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca²⁺-induced contractions of rabbit aorta respectively; EC₂₅ = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo, exerting primary effects on vascular tissue with secondary negative chronotropic action.

Technical Data

M.Wt:

371.39

Formula:

C₁₉H₂₁N₃O₅

Solubility:

Soluble to 50 mM in DMSO and to 20 mM in ethanol

Purity:

≥98%

Storage:

Store at RT

CAS No:

75695-93-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta.
Hof et al.
J.Cardiovasc.Pharmacol., 1984;6:399
Separation of the coronary vasodilator from the cardiac effects of PN 200-110, a new dihydropyridine calcium antagonist, in the dog heart.
Wada et al.
J.Cardiovasc.Pharmacol., 1985;7:190
Pharmacology of the calcium antagonist israd.
Ruegg and Hof
Drugs, 1990;40:3

Product Datasheets

COA view current batch

SDS

Citations for Isradipine

The citations listed below are publications that use Tocris products. Selected citations for Isradipine include:

6 Citations: Showing 1 - 6

An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
Authors: McKeithan Et al.
Front Physiol 2017;8:766
Inflammation alters AMPA-stimulated calcium responses in dorsal striatal D2 but not D1 spiny projection neurons.
Authors: Winland Et al.
Eur J Neurosci 2017;46:2519
Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology.
Authors: Pourbadie Et al.
J Neurosci 2015;10:e0117555
Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra DA neurons.
Authors: Dragicevic Et al.
PLoS One 2014;137:2287
A mammalian retinal bipolar cell uses both graded changes in membrane voltage and all-or-nothing Na+ spikes to encode light.
Authors: Saszik and DeVries
J Neurosci 2012;32:297
Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
Authors: Murray Et al.
J Neurophysiol 2011;106:925

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Isradipine

There are currently no reviews for this product. Be the first to review Isradipine and earn rewards!

Have you used Isradipine?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.