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Isoproterenol hydrochloride

Catalog #: 1747
27 Citations Datasheet
Catalog # Availability Size / Price Qty
1747/100
Isoproterenol hydrochloride | CAS No. 51-30-9 | Non-selective Adrenergic beta Receptor Agonists
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Description: Standard selective β agonist
Alternative Names: Isoprenaline

Chemical Name: 4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol hydrochloride

Purity: ≥98%

Product Details
Citations (27)
Reviews
Biological Activity Scientific Data Technical Data Background Product Datasheets Calculators

Biological Activity

Isoproterenol hydrochloride is a standard selective β-adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo.

Scientific Data

Binding Activity Isoproterenol affects the rate of cardiomyocyte contraction View Larger

Small molecules affect the rate of cardiomyocyte contraction. Cardiomyocytes were differentiated from the BG01V human embryonic stem cells and assessed for their ability to contract using the Fluo-4 calcium binding assay. Rate interval graph show fluctuations in Fluo-4 fluorescence intensity, indicative of cardiomyocyte contraction, under basal conditions (brown; untreated) and following sequential treatment with Isoproterenol (blue; Catalog # 1747), a beta -adrenergic agonist, and Propranolol (tan; Catalog # 0624), a beta -adrenergic antagonist. Table shows drug concentrations and contraction rate of cardiomyocytes during each treatment. The contraction rate of differentiated cardiomyocytes was determined as the number of contractions (contraction-interval plus relaxation interval) per minute.

Technical Data

M.Wt:
247.72
Formula:
C11H17NO3.HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Store at RT
CAS No:
51-30-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Isoproterenol hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Isoproterenol hydrochloride include:

27 Citations: Showing 1 - 10

  1. Increased clusterin levels after myocardial infarction is due to a defect in protein degradation systems activity.
    Authors: Turkieh Et al.
    Cell Death Dis  2019;10:608
  2. Female Mice Have Higher Angiogenesis in Perigonadal Adipose Tissue Than Males in Response to High-Fat Diet.
    Authors: Rudnicki Et al.
    Front Physiol  2018;9:1452
  3. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
    Authors: McKeithan Et al.
    Front Physiol  2017;8:766
  4. Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium.
    Authors: Hernández-Cascales
    PeerJ  2017;5:e3113
  5. Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5.
    Authors: Komolov Et al.
    Cell  2017;169:407
  6. DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH.
    Authors: Liu Et al.
    FASEB J  2016;30:635
  7. Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart.
    Authors: Lang Et al.
    Cereb Cortex  2015;8:409
  8. Optodynamic simulation of β-adrenergic receptor signalling.
    Authors: Siuda Et al.
    Circ Arrhythm Electrophysiol  2015;6:8480
  9. Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling.
    Authors: Sun Et al.
    Nat Commun  2015;5:15950
  10. Locus Coeruleus Stimulation Facilitates Long-Term Depression in the Dentate Gyrus That Requires Activation of β-Adrenergic Receptors.
    Authors: Hansen and Manahan-Vaughan
    Eur J Neurosci  2015;25:1889
  11. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods  2015;12:661
  12. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote.
    Authors: Merino Et al.
    J Mol Cell Cardiol  2015;10:e0132884
  13. Excitatory drive onto DArgic neurons in the rostral linear nucleus is enhanced by NE in an α1 adrenergic receptor-dependent manner.
    Authors: Williams Et al.
    Neuropharmacology  2014;86:116
  14. PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling.
    Authors: Yang Et al.
    Diabetes  2014;66:83
  15. Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
    Authors: Gray Et al.
    Biochem Biophys Res Commun  2014;289:14600
  16. NE drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors.
    Authors: Zhang Et al.
    PLoS One  2013;8:e66122
  17. Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala.
    Authors: Silberman and Winder
    Neuropharmacology  2013;70:316
  18. Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion.
    Authors: Zaytseva Et al.
    Sens Actuators B Chem  2013;188
  19. Age-related impairment in Ins release: the essential role of β(2)-adrenergic receptor.
    Authors: Santulli Et al.
    J Cell Biol  2012;61:692
  20. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
    Authors: Rankovic Et al.
    PLoS One  2011;6:e27474
  21. β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism.
    Authors: Nobis Et al.
    Biol Psychiatry  2011;69:1083
  22. Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4.
    Authors: Chigaev Et al.
    J Biol Chem  2011;286:20375
  23. NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology  2011;152:3842
  24. Reversibly sealed multilayer microfluidic device for integrated cell perfusion and on-line chemical analysis of cultured adipocyte secretions.
    Authors: Clark Et al.
    Anal Bioanal Chem  2010;397:2939
  25. The effects of aging and chronic fluox. treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors.
    Authors: Duncan Et al.
    J Biol Chem  2010;31:1646
  26. Bitter peptides activate hTAS2Rs, the human bitter receptors.
    Authors: Maehashi Et al.
    PLoS One  2008;365:851
  27. Noradrenergic inputs mediate state dependence of auditory responses in the avian song system.
    Authors: Cardin and Schmidt
    Sci Rep  2004;24:7745

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