Isoginkgetin
Chemical Name: 8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98%
Biological Activity
Isoginkgetin is a pre-mRNA splicing inhibitor (IC50 ~ 30 μM); inhibits major and minor spliceosomes. Suppresses transcriptional elongation. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage. Does not inhibit CDK9. Inhibits tumor cell invasion. Active in vivo. Cell permeableTechnical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.
O'Brien et al.
J.Biol.Chem., 2008;283:33147 -
The right tool for the job.
Szewczak et al.
Cell, 2017;169:561 -
Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis.
Boswell et al.
Nat.Chem.Biol., 2017;13:501
Product Datasheets
Citation for Isoginkgetin
The citations listed below are publications that use Tocris products. Selected citations for Isoginkgetin include:
1 Citation: Showing 1 - 1
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Alternative splicing is a developmental switch for hTERT expression.
Authors: Sharon A Et al.
Mol Cell 2021;81:2349-2360.e6
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