iso-PPADS tetrasodium salt
Chemical Name: Pyridoxalphosphate-6-azophenyl-2',5'-disulfonic acid tetrasodium salt
Biological Activity
iso-PPADS tetrasodium salt is a P2X-purinoceptor antagonist (pKi = 6.5) with similar activity to PPADS.2'4'-isomer also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Differentiation by pyridoxal 5-phosphate, PPADS and isoPPADS between responses mediated by UTP and those evoked by α,β-methylene-ATP on rat sympathetic ganglia.
Connolly
Br.J.Pharmacol., 1995;114:727 -
Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens.
Khakh et al.
Eur.J.Pharmacol., 1994;263:301 -
The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by α,β-methylene adenosine 5'-triphosphate.
Trezise et al.
Br.J.Pharmacol., 1994;112:282
Product Datasheets
Citations for iso-PPADS tetrasodium salt
The citations listed below are publications that use Tocris products. Selected citations for iso-PPADS tetrasodium salt include:
5 Citations: Showing 1 - 5
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Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.
Authors: Uderhardt Et al.
Cell 2019;177:541
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Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes.
Authors: Barría Et al.
Am J Trop Med Hyg 2018;98:105
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Characterization of purinergic receptor expression in ARPKD cystic epithelia.
Authors: Palygin Et al.
Purinergic Signal 2018;14:485
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Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells.
Authors: Schneider Et al.
Am J Physiol Renal Physiol 2015;14:201
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Glial cells modulate the synaptic transmission of NTS neurons sending projections to ventral medulla of Wistar rats.
Authors: Accorsi-Mendonça Et al.
Physiol Rep 2013;1:e00080
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