Ischemin sodium salt

Catalog #: 4695 Datasheet

Catalog #	Availability	Size / Price	Qty
4695/10
4695/50

Ischemin sodium salt | Bromodomain Inhibitors

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Description: CBP inhibitor; cell permeable

Chemical Name: 5-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid sodium salt

Purity: ≥99%

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Product Details

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Ischemin sodium salt is a CBP bromodomain inhibitor. Inhibits p53 interaction with CBP and decreases p53 transcriptional activity. Protects against Doxorubicin-induced apoptosis in cardiomyocytes in vitro. Cell permeable.

Technical Data

M.Wt:

357.36

Formula:

C₁₅H₁₆N₃O₄SNa

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥99%

Storage:

Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes.
Borah et al.
Chem.Biol., 2011;18:531

Product Datasheets

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SDS

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