IOX 2
Chemical Name: N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
Purity: ≥99%
Biological Activity
IOX 2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3. Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity.
Murray et al.
J.Comb.Chem., 2010;12:676
Product Datasheets
Citations for IOX 2
The citations listed below are publications that use Tocris products. Selected citations for IOX 2 include:
2 Citations: Showing 1 - 2
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Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL.
Authors: Christopher J Et al.
Cancer Res 2022;82:3375-3393
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Hypoxic preconditioning protects against ischemic kidney injury through the IDO1/kynurenine pathway.
Authors: Navdeep S Et al.
Cell Rep 2021;36:109547
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