IOX 1
Chemical Name: 8-Hydroxy-5-quinolinecarboxylic acid
Purity: ≥99%
Biological Activity
IOX 1 is a histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; it inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. IOX 1 suppresses IL-17 expression in mouse and human CD4+ T cells by targeting TET2. It also reduces infiltration of Th17 cells in an in vivo model of intraocular inflammation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.
King et al.
PLoS One., 2010;5:e15535
Product Datasheets
Citations for IOX 1
The citations listed below are publications that use Tocris products. Selected citations for IOX 1 include:
3 Citations: Showing 1 - 3
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Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL.
Authors: Christopher J Et al.
Cancer Res 2022;82:3375-3393
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A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival.
Authors: Sandra Et al.
Cell Death Dis 2021;12:573
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Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.
Authors: Li Et al.
Nat Commun 2018;9:1420
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