Insect Cathepsin L Antibody Summary
Applications
Recombinant Insect Cathepsin L
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Cathepsin L
The pro form of insect cell Cathepsin L is stable at neutral pH, but autoactivates in acidic buffers under reducing conditions. The activated enzyme is similar in substrate specificity to mammalian Cathepsin L, and is very active as a protease, as judged by its ability to degrade azocasein. Cystatins A, B, C, E/M, F, SA, and SN are potent inhibitors of the insect cell Cathepsin L. Like other cysteine proteases related to papain, insect cell Cathepsin L is also inhibited by E-64 and reagents which react with thiols.
Product Datasheets
Citations for Insect Cathepsin L Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
15
Citations: Showing 1 - 10
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Genetic analysis of the Drosophila ESCRT-III complex protein, VPS24, reveals a novel function in lysosome homeostasis
Authors: JR Florian, SJ DeMatte, DM Sweeder, RW Ordway, F Kawasaki
PLoS ONE, 2021-05-06;16(5):e0251184.
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Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi
Authors: Torsten W.B. Götz, Dmytro Puchkov, Veronika Lysiuk, Janine Lützkendorf, Alexander G. Nikonenko, Christine Quentin et al.
Journal of Cell Biology
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Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity
Authors: Meigen Yu, Hui Ye, Ruth B. De-Paula, Carl Grant Mangleburg, Timothy Wu, Tom V. Lee et al.
PLOS Genetics
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Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain
Authors: Hui Ye, Shamsideen A Ojelade, David Li-Kroeger, Zhongyuan Zuo, Liping Wang, Yarong Li et al.
eLife
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Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia
Authors: L Wang, G Lin, Z Zuo, Y Li, SK Byeon, A Pandey, HJ Bellen
Oncogene, 2022-07-13;8(28):eabn3326.
Species: Drosophila melanogaster
Sample Types: Whole Tissue
Applications: IHC -
Phenylbutyrate modulates polyamine acetylase and ameliorates Snyder-Robinson syndrome in a Drosophila model and patient cells
Authors: X Tao, Y Zhu, Z Diaz-Perez, SH Yu, JR Foley, TM Stewart, RA Casero, R Steet, RG Zhai
JCI Insight, 2022-07-08;7(13):.
Species: Drosophila melanogaster
Sample Types: Tissue Homogenates, Whole Tissue
Applications: IHC, Western Blot -
Integrated analysis of the aging brain transcriptome and proteome in tauopathy
Authors: CG Mangleburg, T Wu, HK Yalamanchi, C Guo, YC Hsieh, DM Duong, EB Dammer, PL De Jager, NT Seyfried, Z Liu, JM Shulman
Mol Neurodegener, 2020-09-29;15(1):56.
Species: Drosophila
Sample Types: Tissue Homogenates
Applications: Western Blot -
Lysosomal Machinery Drives Extracellular Acidification to Direct Non-apoptotic Cell Death
Authors: AA Mondragon, A Yalonetska, AJ Ortega, Y Zhang, O Naranjo, J Elguero, WS Chung, K McCall
Cell Rep, 2019-04-02;27(1):11-19.e3.
Applications: IHC -
Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification
Authors: M ?entürk, G Lin, Z Zuo, D Mao, E Watson, AG Mikos, HJ Bellen
Nat. Cell Biol., 2019-02-25;21(3):384-396.
Species: Insect
Sample Types: Cell Lysates
Applications: Western Blot -
VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway
Authors: D Mao, G Lin, B Tepe, Z Zuo, KL Tan, M Senturk, S Zhang, BR Arenkiel, M Sardiello, HJ Bellen
Autophagy, 2019-02-20;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome
Authors: C Li, JM Brazill, S Liu, C Bello, Y Zhu, M Morimoto, L Cascio, R Pauly, Z Diaz-Perez, MCV Malicdan, H Wang, L Boccuto, CE Schwartz, WA Gahl, CF Boerkoel, RG Zhai
Nat Commun, 2017-11-02;8(1):1257.
Species: Drosophila
Sample Types: Tissue Homogenates
Applications: Western Blot -
The unique GGA clathrin adaptor of Drosophila melanogaster is not essential.
Authors: Luan S, Ilvarsonn A, Eissenberg J
PLoS ONE, 2012-09-20;7(9):e45163.
Species: Drosophila
Sample Types: Tissue Homogenates
Applications: Western Blot -
Characterization of cathepsin L secreted by Sf21 insect cells.
Authors: Johnson GD, Jiang W
Arch. Biochem. Biophys., 2005-10-21;444(1):7-14.
Species: Insect
Sample Types: Cell Culture Supernates
Applications: Immunoprecipitation, Western Blot -
The lysosomal enzyme receptor protein (LERP) is not essential, but is implicated in lysosomal function in Drosophila melanogaster
Authors: Medina Hasanagic, Eline van Meel, Shan Luan, Rajeev Aurora, Stuart Kornfeld, Joel C. Eissenberg
Biology Open
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The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling
Authors: Caitlin E. O’Brien, Susan H. Younger, Lily Yeh Jan, Yuh Nung Jan
Journal of Cell Biology
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