Influenza A Virus H1N1 Neuraminidase Antibody Summary
Ser37-Lys469
Accession # AAF77036
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Viral Neuraminidase
Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. HA is a lectin that binds sialic acid on host cell membrane. NA is a sialic acid hydrolase that specifically clips off terminally located sialic acid on host cell surface. The two proteins are essential for the infectious cycle of the influenza virus. During initial infection, an influenza virus will hold onto an epithelial cell through HA-sialic acid interaction. At the end of an infectious cycle, the NA will cleave the sialic acid on the host cell membrane, releasing the formed viral particle from the HA-sialic acid bondage (1). The neuraminidase activity is also thought to help the virus penetrate mucus. Nine subtypes of NA have been identified, all of which are tetrameric and share a common structure consisting of a globular head, a thin stalk region, and a small hydrophobic region that anchors the protein in the virus membrane (2). The purified recombinant viral H1N1NA consists of amino acid residues 37 to 469 as deduced from the 1918 Spanish flu virus NA (A/Bervig_Mission/1/18) (3). It has a distinct N-glycan profile and is resistant to trypsin digestion (4).
Product Datasheets
Citations for Influenza A Virus H1N1 Neuraminidase Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Apical Trafficking Pathways of Influenza A Virus HA and NA via Rab17- and Rab23-Positive Compartments
Authors: Ryota Sato, Takashi Okura, Madoka Kawahara, Naoki Takizawa, Fumitaka Momose, Yuko Morikawa
Frontiers in Microbiology
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Cell-Based Influenza A/H1N1pdm09 Vaccine Viruses Containing Chimeric Hemagglutinin with Improved Membrane Fusion Ability
Authors: M Kawahara, T Wada, F Momose, E Nobusawa, Y Morikawa
Vaccines (Basel), 2020-08-19;8(3):.
Species: Canine, Human, Mouse
Sample Types: Cell Lysates, Protein
Applications: Western Blot -
Influenza A Virus Hemagglutinin is Required for the Assembly of Viral Components Including Bundled vRNPs at the Lipid Raft
Viruses, 2016-09-10;8(9):.
Species: Canine
Sample Types: Cell Lysates
Applications: Western Blot -
DNA-linked inhibitor antibody assay (DIANA) as a new method for screening influenza neuraminidase inhibitors
Authors: Milan Kožíšek, Václav Navrátil, Kateřina Rojíková, Jana Pokorná, Carlos Berenguer Albiñana, Petr Pachl et al.
Biochemical Journal
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