INF 39
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Description: Irreversible NLRP3 inhibitor
Chemical Name: Ethyl 2-(2-chlorobenzyl)acrylate
Purity: ≥98%
Biological Activity
INF 39 is an irreversible NLRP3 inhibitor (exhibits 52% inhibition of NLRP3 ATPase at 100 μM). Inhibits IL-1β release, caspase activation and pyroptosis in THP-1 cells. Reduces inflammation in a rat colitis model. Exhibits low cytotoxicity.Technical Data
M.Wt:
224.68
Formula:
C12H13ClO2
Solubility:
Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
866028-26-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Development of an acrylate derivative targeting the NLRP3 inflammasome for the treatment of inflammatory bowel disease.
Cocco et al.
J.Med.Chem., 2017;60:3656
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