Home / Chemokine Receptor Antagonists / INCB 3284 dimesylate

INCB 3284 dimesylate

Catalog #: 4306
3 Citations Datasheet
Catalog # Availability Size / Price Qty
4306/10
4306/50
INCB 3284 dimesylate | CAS No. 887401-93-6 | Chemokine Receptor Antagonists
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Description: Selective CCR2 antagonist

Chemical Name: N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity

INCB 3284 dimesylate is a potent, selective hCCR2 antagonist. Exhibits potent antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). Also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84μ M). Orally bioavailable.

Technical Data

M.Wt:
712.76
Formula:
C26H31F3N4O4.2CH4O3S
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
887401-93-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for INCB 3284 dimesylate

The citations listed below are publications that use Tocris products. Selected citations for INCB 3284 dimesylate include:

3 Citations: Showing 1 - 3

  1. Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways.
    Authors: Liu Et al.
    Cancer Lett.  2016;379:49
  2. Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation.
    Authors: Zhou Et al.
    Nat Commun  2015;26:121
  3. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline.
    Authors: McMillin Et al.
    J Neuroinflammation  2014;11:121

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