iCRT 14
Chemical Name: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedion
Purity: ≥98%
Biological Activity
iCRT 14 is a potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. Also acts as transfection enhancer; enhances transgene expression in PC-3 cells by 16 to 35-fold using nonviral systems.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells
BA Brown, GM Connolly, CEJ Mill, H Williams, GD Angelini, JL Johnson, SJ George
Aging Cell, 2018;0(0):e12844. -
Remote activation of the Wnt/beta-catenin signalling pathway using functionalised magnetic particles.
Rotherham M, El Haj A
PLoS ONE, 2015;10(3):e0121761. -
Targeting Wnt pathway in mantle cell lymphoma-initiating cells.
Mathur R, Sehgal L, Braun F, Berkova Z, Romaguerra J, Wang M, Rodriguez M, Fayad L, Neelapu S, Samaniego F
J Hematol Oncol, 2015;8(0):63. -
Enhancement of transgene expression by the β-catenin inhibitor iCRT14.
Spivack et al.
Plasmid, 2021;
Product Datasheets
Citations for iCRT 14
The citations listed below are publications that use Tocris products. Selected citations for iCRT 14 include:
9 Citations: Showing 1 - 9
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Pro-inflammatory role of Wnt/β-catenin signaling in endothelial dysfunction.
Authors: Sarah J Et al.
Front Cardiovasc Med 2023;9:1059124
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Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
Authors: Ling Et al.
Cell Stem Cell 2021;28:1090-1104.e6
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Heparanase-Induced Activation of AKT Stabilizes β-Catenin and Modulates Wnt/β-Catenin Signaling during Herpes Simplex Virus 1 Infection.
Authors: Alex M Et al.
MBio 2021;12:e0279221
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Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation.
Authors: Paula Et al.
Dev Cell 2020;53:545-560.e7
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Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells.
Authors: Brown Et al.
Aging Cell 2019;18:e12844
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Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages.
Authors: Volpini Et al.
Front Immunol 2018;9:859
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Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-β-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression.
Authors: Gowda Et al.
Mol Cell Biol 2018;38
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Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.
Authors: Kennedy Et al.
Proc Natl Acad Sci U S A 2016;113:3545
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Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation.
Authors: Wu Et al.
J Neurosci 2012;32:6651
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