ICI 182,780
Chemical Name: 7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol
Purity: ≥99%
Biological Activity
ICI 182,780 is a high affinity estrogen receptor antagonist (IC50 = 0.29 nM), devoid of any partial agonism both in vitro and in vivo. ICI 182,780 is a high affinity agonist at the membrane estrogen receptor GPER. ICI 182,780 inhibits MCF-7 human breast cancer cell growth in vitro and shows antitumor activity in mice models. ICI 182,780 penetrates the blood-brain-barrier and has neuronal functional effects in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Estrogen Regulates Hepcidin Expression via GPR30-BMP6-Dependent Signaling in Hepatocytes.
Ikeda Y, Tajima S, Izawa-Ishizawa Y, Kihira Y, Ishizawa K, Tomita S, Tsuchiya K, Tamaki T
PLoS ONE, 2012;7(7):e40465. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
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Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Estradiol reduces ferrous citrate complex-induced NOS2 up-regulation in cerebral endothelial cells by interfering the nuclear factor kappa B transactivation through an estrogen receptor beta-mediated pathway.
Chen L, Lee W
PLoS ONE, 2013;8(12):e84320. -
Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir
B Das, C Dobrowolsk, B Luttge, S Valadkhan, N Chomont, R Johnston, P Bacchetti, R Hoh, M Gandhi, SG Deeks, E Scully, J Karn
Proc. Natl. Acad. Sci. U.S.A., 2018;115(33):E7795-E7804. -
Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.
Litchfield LM, Riggs KA, Hockenberry AM, Oliver LD, Barnhart KG, Cai J, Pierce WM, Ivanova MM, Bates PJ, Appana SN, Datta S, Kulesza P, McBryan J, Young LS, Klinge CM
PLoS ONE, 2012;7(5):e38278. -
Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness.
Cook K, Shajahan A, Warri A, Jin L, Hilakivi-Clarke L, Clarke R
Cancer Res, 2012;72(13):3337-49. -
PHLDA1 expression is controlled by an estrogen receptor-NFkappaB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres.
Kastrati I, Canestrari E, Frasor J
Oncogene, 2015;34(18):2309-16. -
ERbeta-mediated estradiol enhances epithelial mesenchymal transition of lung adenocarcinoma through increasing transcription of midkine.
Mol. Endocrinol., 2012;26(8):1304-15. -
Epidermal growth factor receptor (EGFR) signaling is a key mediator of hormone-induced leukocyte infiltration in the pubertal female mammary gland.
Aupperlee M, Zhao Y, Tan Y, Leipprandt J, Bennett J, Haslam S, Schwartz R
Endocrinology, 2014;155(6):2301-13. -
Estrogen receptor (ER) agonists differentially regulate neuroangiogenesis in peritoneal endometriosis via the repellent factor SLIT3.
Greaves E, Collins F, Esnal-Zufiaurre A, Giakoumelou S, Horne A, Saunders P
Endocrinology, 2014;155(10):4015-26. -
Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the hematopoietic estrogen receptor alpha.
Valera M, Gratacap M, Gourdy P, Lenfant F, Cabou C, Toutain C, Marcellin M, Saint Laurent N, Sie P, Sixou M, Arnal J, Payrastre B
Blood, 2012;120(8):1703-12. -
The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.
Privette Vinnedge L, Ho S, Wikenheiser-Brokamp K, Wells S
PLoS ONE, 2012;7(10):e46985. -
The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines.
Kirkegaard T, Yde C, Kveiborg M, Lykkesfeldt A
Int J Oncol, 2014;45(1):393-400. -
D538G mutation in estrogen receptor-alpha: A novel mechanism for acquired endocrine resistance in breast cancer.
Merenbakh-Lamin K, Ben-Baruch N, Yeheskel A, Dvir A, Soussan-Gutman L, Jeselsohn R, Yelensky R, Brown M, Miller V, Sarid D, Rizel S, Klein B, Rubinek T, Wolf I
Cancer Res, 2013;73(23):6856-64. -
Inhibition of ERbeta induces resistance to cisplatin by enhancing Rad51-mediated DNA repair in human medulloblastoma cell lines.
Wilk A, Waligorska A, Waligorski P, Ochoa A, Reiss K
PLoS ONE, 2012;7(3):e33867. -
Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts.
Richardson TE, Yu AE, Wen Y, Yang SH, Simpkins JW
PLoS ONE, 2012;7(4):e34600. -
Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.
Thomas et al.
Endocrinology, 2005;146:624 -
Comparison between novel steroid-like and conventional nonsteroidal antioestrogens in inhibiting OE and IGF-I induced proliferation of human breast cancer-derived cells.
de Cupis et al.
Br.J.Pharmacol., 1995;116:2391 -
ICI 182,780 (FaslodexTM): Development of a novel, "pure" antiestrogen.
Howell et al.
Cancer, 2000;89:817 -
A potent specific pure antiestrogen with clinical potential.
Wakeling et al.
Cancer Res., 1991;51:3867
Product Datasheets
Citations for ICI 182,780
The citations listed below are publications that use Tocris products. Selected citations for ICI 182,780 include:
284 Citations: Showing 1 - 10
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Pancreatic Ins content regulation by the estrogen receptor ER alpha.
Authors: Alonso-Magdalena Et al.
PLoS One ;3:e2069
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Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer.
Authors: Demas Et al.
Front Oncol 2019;9:686
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Chronic cadmium exposure decreases the dependency of MCF7 breast cancer cells on ERα.
Authors: Bloomfield and Louie
Sci Rep 2019;9:12135
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TAX mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor.
Authors: Cortes Et al.
Oncogene 2019;38:2910
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Data on UPLC/MS method validation for the biodegradation of pharmaceuticals and intermediates by a fungal consortium and on T47DK-Bluc reporter gene assay to assess the reduction of their estrogenic activity.
Authors: Kasonga Et al.
Data Brief 2019;25:104336
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GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment.
Authors: Cortes Et al.
EMBO Rep 2019;20
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TAX mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival.
Authors: Cortes Et al.
EMBO Rep 2019;20
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F-Spondin Is the Signal by Which 2-Methoxyestradiol Induces Apoptosis in the Endometrial Cancer Cell Line Ishikawa.
Authors: Rincó n-Rodriguez Et al.
Int J Mol Sci 2019;20
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Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer.
Authors: Hosford Et al.
Mol Oncol 2019;13:1778
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Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance.
Authors: Kaymak Et al.
Oncotarget 2018;9:28666
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Brain Aromatase Modulates Serotonergic Neuron by Regulating Serotonin Levels in Zebrafish Embryos and Larvae.
Authors: Ulhaq and Kishida
Front Endocrinol (Lausanne) 2018;9:230
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A transcriptomics model of estrogen action in the ovine fetal hypothalamus: evidence for estrogenic effects of ICI 182,780.
Authors: Rabaglino Et al.
Physiol Rep 2018;6:e13871
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17β-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes.
Authors: Jallow Et al.
J Endocr Soc 2018;2:293
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The impact of 27-hydroxycholesterol on endometrial cancer proliferation.
Authors: Gibson Et al.
Endocr Relat Cancer 2018;25:381
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Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer.
Authors: Du Et al.
Breast Cancer Res 2018;20:106
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Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells.
Authors: Li Et al.
Endocrinology 2018;159:285
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Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors.
Authors: Simões Et al.
Ther Adv Med Oncol 2018;10:1758835918766180
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Estrogen enhances mismatch repair by induction of MLH1 expression via estrogen receptor-β.
Authors: Lu Et al.
Oncotarget 2017;8:38767
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Structural and molecular mechanisms of cytokine-mediated endocrine resistance in human breast cancer cells.
Authors: Stender
Mol Cell 2017;65(6):1122
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E2 via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells.
Authors: Panza Et al.
Tumour Biol 2017;39:1010428317701640
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Role of inducible nitric oxide synthase in endothelium-independent relaxation to RLX in rat aorta.
Authors: Wong Et al.
Br J Pharmacol 2017;174:718
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OE Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory TH2 Shift by Activating SGK1.
Authors: Lou Et al.
Int J Biol Sci 2017;13:434
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Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors.
Authors: Zhu
PLoS One 2017;12(2):e0171390
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Identification of Differential ER-Alpha Versus ER-Beta Mediated Activation of eNOS in Ovine Uterine Artery Endothelial Cells.
Authors: Pastore Et al.
Biol Reprod 2016;94:139
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Multiple direct and indirect mechanisms drive estrogen-induced tumor growth in high grade serous ovarian cancers.
Authors: Ciucci Et al.
Oncotarget 2016;7:8155
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Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus.
Authors: Maselli Et al.
Front Vet Sci 2016;7:3
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Antiestrogen resistant cell lines expressing estrogen receptor α mutations upregulate the unfolded protein response and are killed by BHPI
Authors: Mao Et al.
Scientific Reports 2016;6:34753
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Estrogen protects against DA neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway.
Authors: Bains and Roberts
Neurosci Lett 2016;610:79
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NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer.
Authors: Gupta Et al.
Oncogene 2016;35:5860
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Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors.
Authors: Peretz Et al.
Am J Physiol Lung Cell Mol Physiol 2016;310:L415
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Progesterone induces progesterone receptor gene (PGR) expression via rapid activation of protein kinase pathways required for cooperative estrogen receptor alpha (ER) and progesterone receptor (PR) genomic action at ER/PR target genes.
Authors: Diep Et al.
Steroids 2016;114:48
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Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
Authors: Tozzi Et al.
Front Cell Neurosci 2015;9:192
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Differential effects of estrogen and estrogen receptor antagonist, ICI 182 780, on the expression of calbindin-D9k in rat pituitary prolactinoma GH3 cells.
Authors: Wang Et al.
Cancer Cell Int 2015;7:8498
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A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation.
Authors: Tomita Et al.
Nat Commun 2015;6:6966
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A short report: PAMM, a novel antioxidant protein, induced by oxidative stress.
Authors: Xu Et al.
Redox Biol 2015;6:446
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Altered radiation responses of breast cancer cells resistant to hormonal therapy.
Authors: Luzhna Et al.
Mol Cell Biol 2015;6:1678
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Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro.
Authors: Harvey Et al.
Reprod Toxicol 2015;51:72
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Nodes-and-connections RNAi knockdown screening: identification of a signaling molecule network involved in fulves. action and breast cancer prognosis.
Authors: Miyoshi Et al.
Biol Sex Differ 2015;4:e172
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Differential expression of upstream stimulatory factor (USF) 2 variants in eutopic endometria from women with endometriosis: OE regulation.
Authors: Castro Et al.
Biol Res 2015;48:56
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New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulves. treatment and cross-resistance between letr. and exeme.
Authors: Hole Et al.
BMC Cancer 2015;46:1481
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NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer.
Authors: Hu Et al.
Oncogenesis 2015;35:379
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PHLDA1 expression is controlled by an estrogen receptor-NFκB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres.
Authors: Kastrati Et al.
Oncogene 2015;34:2309
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The Effects of Steroid Implant and Dietary Soybean Hulls on Estrogenic Activity of Sera of Steers Grazing Toxic Endophyte-Infected Tall Fescue Pasture.
Authors: Shappell Et al.
Cancer Lett 2015;2:30
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Estrogenic and anti-estrogenic activity of off-the-shelf hair and skin care products.
Authors: Myers Et al.
BMC Cancer 2015;25:271
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Effects of estrogen on growth and smooth muscle differentiation of vascular wall-resident CD34(+) stem/progenitor cells.
Authors: Wu Et al.
Atherosclerosis 2015;240:453
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Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader.
Authors: Wardell Et al.
Endocr Relat Cancer 2015;22:713
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Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamox. resistant breast cancer.
Authors: Larsen Et al.
Aging Cell 2015;15:239
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Antihormonal agents as a strategy to improve the effect of chemo-radiation in cervical cancer: in vitro and in vivo study.
Authors: Segovia-Mendoza Et al.
J Biol Chem 2015;15:21
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Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway.
Authors: Xiong Et al.
Breast Cancer Res Treat 2015;14:867
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Estrogen mediated expression of nucleophosmin 1 in human endometrial carcinoma clinical stages through estrogen receptor-α signaling.
Authors: Zhou Et al.
Endocrinology 2015;14:540
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The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer.
Authors: Bean Et al.
Oncotarget 2015;149:69
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Estrogen promotes luteolysis by redistributing prostaglandin F2α receptors within primate luteal cells.
Authors: Kim Et al.
Reproduction 2015;149:453
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Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.
Authors: Simões Et al.
Cell Cycle 2015;12:1968
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Effects of Atrazine on Estrogen Receptor α- and G Protein-Coupled Receptor 30-Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts.
Authors: Albanito Et al.
Environ Health Perspect 2015;123:493
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Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis.
Authors: Gottardo Et al.
PLoS One 2014;9:e111548
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Comprehensive analysis of prostaglandin metabolic enzyme expression during pregnancy and the characterization of AKR1B1 as a prostaglandin F synthase at the maternal-conceptus interface in pigs.
Authors: Seo Et al.
Breast Cancer Res 2014;90:99
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Diaryl and heteroaryl sulfides: synthesis via sulfenyl chlorides and evaluation as selective anti-breast-cancer agents.
Authors: Yonova Et al.
J Org Chem 2014;79:1947
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Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin Cytoskeleton.
Authors: Giretti Et al.
Front Endocrinol (Lausanne) 2014;5:80
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Functional analysis of MKP-1 and MKP-2 in breast cancer tamox. sensitivity.
Authors: Haagenson Et al.
Oncotarget 2014;5:1101
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Inhibition of c-Src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells.
Authors: Fan Et al.
Eur J Cancer 2014;50:457
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A molecular model for the mechanism of acquired tamox. resistance in breast cancer.
Authors: Fan Et al.
Eur J Cancer 2014;50:2866
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Anti-tumor efficacy of fulves. in estrogen receptor positive gastric cancer.
Authors: Yi Et al.
Sci Rep 2014;4:7592
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β-D-glucan inhibits endocrine-resistant breast cancer cell proliferation and alters gene expression.
Authors: Jafaar Et al.
Int J Oncol 2014;44:1365
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Oestrogen upregulates the sarcoplasmic reticulum Ca(2+) ATPase pump in coronary arteries.
Authors: Hill and Muldrew
Clin Exp Pharmacol Physiol 2014;41:430
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Egr1 protein acts downstream of estrogen-leukemia inhibitory factor (LIF)-STAT3 pathway and plays a role during implantation through targeting Wnt4.
Authors: Liang Et al.
J Biol Chem 2014;289:23534
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Activation of a Gq-coupled membrane estrogen receptor rapidly attenuates α2-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat.
Authors: Nag and Mokha
Am J Physiol Regul Integr Comp Physiol 2014;267:122
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Suppression of autophagic activation in the mouse uterus by estrogen and progesterone.
Authors: Choi Et al.
Cell Rep 2014;221:39
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Hormonal regulation of epithelial organization in a three-dimensional breast tissue culture model.
Authors: Speroni Et al.
PLoS One 2014;20:42
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In vitro chronic administration of ERbeta selective ligands and prostate cancer cell growth: hypotheses on the selective role of 3beta-adiol in AR-positive RV1 cells.
Authors: Colciago Et al.
Biomed Res Int 2014;2014:801473
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Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86.
Authors: Alao Et al.
BMC Cancer 2014;14:853
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Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover.
Authors: Adomas Et al.
BMC Cancer 2014;14:278
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OE increases cAMP in the oviductal secretory cells through a nongenomic mechanism.
Authors: Oróstica Et al.
Reproduction 2014;148:285
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Estrogen receptor-α signaling and localization regulates autophagy and unfolded protein response activation in ER+ breast cancer.
Authors: Cook and Clarke
Steroids 2014;1
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GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors.
Authors: Morandi Et al.
Cancer Res 2013;73:3783
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Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression.
Authors: Giordano Et al.
Free Radic Biol Med 2013;58:98
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Expression of the aryl hydrocarbon receptor is not required for the proliferation, migration, invasion, or estrogen-dependent tumorigenesis of MCF-7 breast cancer cells.
Authors: Spink Et al.
Mol Carcinog 2013;52:544
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Retinoic acid receptor alpha is associated with tamox. resistance in breast cancer.
Authors: Johansson Et al.
Nat Commun 2013;4:2175
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Induction of hepatic multidrug resistance-associated protein 3 by ethynylOE is independent of cholestasis and mediated by estrogen receptor.
Authors: Ruiz Et al.
Proc Natl Acad Sci U S A 2013;41:275
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The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-OE.
Authors: Smith Et al.
Am J Physiol Endocrinol Metab 2013;305:E632
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ERβ-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1.
Authors: Greaves Et al.
Hum Reprod 2013;28:2490
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The effect of estrogen compounds on human embryoid bodies.
Authors: Kim Et al.
Proc Natl Acad Sci U S A 2013;20:661
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OOE signalling through the Akt-mTORC1-S6K1.
Authors: Varea Et al.
Biochim Biophys Acta 2013;1833:1052
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Amphiregulin mediates progesterone-induced mammary ductal development during puberty.
Authors: Aupperlee Et al.
J Neurosci 2013;15:R44
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OE promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis.
Authors: Aida-Yasuoka Et al.
J Neurosci 2013;15:R10
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Fulvestrant regulates epidermal growth factor (EGF) family ligands to activate EGF receptor (EGFR) signaling in breast cancer cells.
Authors: Zhang Et al.
Environ Health Perspect 2013;139:351
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Differential action of monohydroxylated polycyclic aromatic hydrocarbons with estrogen receptors α and β.
Authors: Sievers Et al.
Proc Natl Acad Sci U S A 2013;132:359
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Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells.
Authors: Teng Et al.
Toxicol Sci 2013;131:71
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17β-OE-induced interaction of ERα with NPPA regulates gene expression in cardiomyocytes.
Authors: Mahmoodzadeh Et al.
Cardiovasc Res 2012;96:411
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Modulation of ovine SBD-1 expression by 17beta-OE in ovine oviduct epithelial cells.
Authors: Wen Et al.
BMC Vet Res 2012;8:143
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Bisphenol A inhibits follicle growth and induces atresia in cultured mouse antral follicles independently of the genomic estrogenic pathway.
Authors: Peretz Et al.
Biol Reprod 2012;87:63
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p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF.
Authors: Leal Et al.
PLoS One 2012;7:e49817
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The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.
Authors: Vinnedge Et al.
Neuroscience 2012;7:e46985
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Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos.
Authors: Brion Et al.
PLoS One 2012;7:e36069
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Insotropic effect of the non-steroidal compound STX in pancreatic β-cells.
Authors: Ropero Et al.
PLoS One 2012;7:e34650
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Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts.
Authors: Richardson Et al.
Endocrinology 2012;7:e34600
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Estrogen receptor β dependent attenuation of cytokine-induced cyclooxygenase-2 by androgens in human brain vascular smooth muscle cells and rat mesenteric arteries.
Authors: Zuloaga Et al.
Exp Neurol 2012;77:835
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Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness.
Authors: Cook Et al.
Int J Mol Sci 2012;72:3337
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Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes.
Authors: Rodriguez-Ubreva Et al.
Nucleic Acids Res 2012;40:1954
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Estrogen receptor is activated by korean red ginseng in vitro but not in vivo.
Authors: Shim and Lee
J Ginseng Res 2012;36:169
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Estrogen-responsive nitroso-proteome in uterine artery endothelial cells: role of endothelial nitric oxide synthase and estrogen receptor-β.
Authors: Zhang Et al.
J Cell Physiol 2012;227:146
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Activation of Estrogen Receptor by Bavachin from Psoralea corylifolia.
Authors: Park Et al.
Proc Natl Acad Sci U S A 2012;20:183
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MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy.
Authors: Bobustuc Et al.
Mol Med 2012;18:913
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OE increases cell growth in human astrocytoma cell lines through ERα activation and its interaction with SRC-1 and SRC-3 coactivators.
Authors: González-Arenas Et al.
Biochim Biophys Acta 2012;1823:379
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Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats.
Authors: Niu Et al.
J Cereb Blood Flow Metab 2012;153:2283
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OE directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons.
Authors: Wang and Kuehl-Kovarik
Brain Res 2012;1436:81
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Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice.
Authors: Babu Et al.
J Nutr 2012;142:724
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Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat.
Authors: Cao Et al.
J Pain 2012;13:685
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Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation.
Authors: Antoon Et al.
Cancer Biol Ther 2012;13:1026
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Antiestrogenic activity of flavonoid phytochemicals mediated via the c-Jun N-terminal protein kinase pathway. Cell-type specific regulation of estrogen receptor alpha.
Authors: Collins-Burow Et al.
J Steroid Biochem Mol Biol 2012;132:186
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Estrogen-like activity of aqueous extract from Agrimonia pilosa Ledeb. in MCF-7 cells.
Authors: Lee Et al.
Endocrinology 2012;12:260
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Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis.
Authors: Youn Et al.
Clin Sci (Lond) 2012;123:509
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Estrogen receptor β (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene.
Authors: Guido Et al.
Int J Clin Exp Pathol 2012;11:2911
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Generation of stable reporter breast cancer cell lines for the identification of ER subtype selective ligands.
Authors: Shanle Et al.
Biochem Pharmacol 2011;82:1940
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17β-OE enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrin.
Authors: Zheng Et al.
PLoS One 2011;6:e22439
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mTOR controls ovarian follicle growth by regulating granulosa cell proliferation.
Authors: Yu Et al.
PLoS One 2011;6:e21415
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Daidzein prevents the increase in CD4+CD28null T cells and B lymphopoesis in ovariectomized mice: a key mechanism for anti-osteoclastogenic effect.
Authors: Tyagi Et al.
PLoS One 2011;6:e21216
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The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes.
Authors: Lappano Et al.
PLoS One 2011;6:e16631
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The effect of 17β-OE on cholesterol content in human macrophages is influenced by the lipoprotein milieu.
Authors: Corcoran Et al.
Clin Cancer Res 2011;47:109
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Complete estrogen receptor blocker ICI182,780 promotes the proliferation of vascular smooth muscle cells.
Authors: He Et al.
Acta Biochim Biophys Sin (Shanghai) 2011;43:118
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Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ- and μ-opioid receptor heterodimerization and female-specific spinal mor. antinociception.
Authors: Liu Et al.
J Neurosci 2011;31:11836
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Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms.
Authors: Burns Et al.
J Biol Chem 2011;286:12640
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Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites.
Authors: Ivanova Et al.
FASEB J 2011;25:1402
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The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects {β}-cells against stress-induced apoptosis.
Authors: Baquié Et al.
FEMS Immunol Med Microbiol 2011;20:2823
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JNK suppression is essential for 17β-OE inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells.
Authors: Hsu Et al.
J Vet Sci 2011;18:61
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Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer.
Authors: Thangavel Et al.
Endocr Relat Cancer 2011;18:333
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Estrogen protection in Friedreich's ataxia skin fibroblasts.
Authors: Richardson Et al.
Endocrinology 2011;152:2742
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Expression and regulation of Enpp2 in rat uterus during the estrous cycle.
Authors: Ahn Et al.
Toxicol Sci 2011;12:379
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17beta-OE inhibits matrix metalloproteinase-2 transcription via MAP kinase in fibroblasts.
Authors: Mahmoodzadeh Et al.
Cardiovasc Res 2010;85:719
-
Developmental exposures of male rats to soy isoflavones impact Leydig cell differentiation.
Authors: Sherrill Et al.
Biol Reprod 2010;83:488
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Interdependence of platelet-derived growth factor and estrogen-signaling pathways in inducing neonatal rat testicular gonocytes proliferation.
Authors: Thuillier Et al.
Biol Reprod 2010;82:825
-
Hepatocyte growth factor system in the mouse uterus: variation across the estrous cycle and regulation by 17-β-OE and progesterone.
Authors: Zhang
Clin Cancer Res 2010;82:1037
-
BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription.
Authors: Harte Et al.
Cancer Res 2010;70:2538
-
Estrogen suppresses MLK3-mediated apoptosis sensitivity in ER+ breast cancer cells.
Authors: Rangasamy Et al.
Cancer Res 2010;70:1731
-
Extranuclear estrogen receptors mediate the neuroprotective effects of estrogen in the rat hippocampus.
Authors: Yang Et al.
PLoS One 2010;5:e9851
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Cell cycle and anti-estrogen effects synergize to regulate cell proliferation and ER target gene expression.
Authors: Dalvai and Bystricky
PLoS One 2010;5:e11011
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Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins.
Authors: Raffetto Et al.
J Vasc Surg 2010;51:972
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OE selectively stimulates endothelial prostacyclin production through estrogen receptor-{alpha}.
Authors: Sobrino Et al.
J Mol Endocrinol 2010;44:237
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Estrogen-receptor-mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro.
Authors: Guo Et al.
PLoS One 2010;30:545
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c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells.
Authors: Madeo Et al.
Oncogene 2010;29:978
-
Estrogen receptor α (ERα) mediates 17β-OE (E2)-activated expression of HBO1.
Authors: Wang Et al.
Proc Natl Acad Sci U S A 2010;29:140
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5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum.
Authors: Foong Et al.
Receptors Clin Investig 2010;298:G384
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Bisphenol A and OE are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells.
Authors: LaPensee Et al.
Cancer Res 2010;290:167
-
Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i
Authors: Sunters Et al.
J Biol Chem 2010;285:8743
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Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testost. on vascular calcification.
Authors: Son Et al.
J Biol Chem 2010;285:7537
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Proinflammatory cytokines enhance estrogen-dependent expression of the multidrug transporter gene ABCG2 through estrogen receptor and NF{kappa}B cooperativity at adjacent response elements.
Authors: Pradhan Et al.
J Biol Chem 2010;285:31100
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Down-regulation of PROS1 gene expression by 17beta-OE via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex.
Authors: Suzuki Et al.
J Biol Chem 2010;285:13444
-
Gender-specific reduction in contraction is associated with increased estrogen receptor expression in single vascular smooth muscle cells of female rat.
Authors: Ma Et al.
Cell Physiol Biochem 2010;26:457
-
Estrogen receptor-alpha promotes breast cancer cell motility and invasion via focal adhesion kinase and N-WASP.
Authors: Sanchez Et al.
Mol Endocrinol 2010;24:2114
-
Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation.
Authors: Peng Et al.
Chem Res Toxicol 2010;23:1374
-
Roles of 17β-OE involve regulation of reelin expression and synaptogenesis in the dentate gyrus.
Authors: Bender Et al.
Cereb Cortex 2010;20:2985
-
Proliferation of human mammary cancer cells exposed to 27-hydroxycholesterol.
Authors: Cruz Et al.
J Expo Sci Environ Epidemiol 2010;1:531
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B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses.
Authors: Lin Et al.
J Immunol 2010;185:2747
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OE suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages.
Authors: Murphy Et al.
J Immunol 2010;184:5029
-
Prolactin and oestrogen synergistically regulate gene expression and proliferation of breast cancer cells.
Authors: Rasmussen Et al.
Endocr Relat Cancer 2010;17:809
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Progesterone increases systemic and local uterine proportions of CD4+CD25+ Treg cells during midterm pregnancy in mice.
Authors: Mao Et al.
Endocrinology 2010;151:5477
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Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640.
Authors: Antoon Et al.
Endocrinology 2010;151:5124
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Estrogen stimulates proliferation and differentiation of neural stem/progenitor cells through different signal transduction pathways.
Authors: Okada Et al.
Am J Physiol Heart Circ Physiol 2010;11:4114
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Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities.
Authors: Allard and Colaiácovo
Proc Natl Acad Sci U S A 2010;107:20405
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Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines.
Authors: Tan Et al.
BMC Cancer 2009;9:31
-
Blockade of estrogen action upregulates estrogen receptor-alpha mRNA in the fetal brain.
Authors: Schaub and Wood
Neonatology 2009;96:115
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Effects of 17beta-oOE on rat detrusor smooth muscle contractility.
Authors: Valeri Et al.
Exp Physiol 2009;94:834
-
The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression.
Authors: Han Et al.
Mol Cancer Res 2009;7:713
-
Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells.
Authors: Bolanz Et al.
Mol Cancer Res 2009;7:2000
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Characterization of a novel small molecule subtype specific estrogen-related receptor alpha antagonist in MCF-7 breast cancer cells.
Authors: Chisamore Et al.
PLoS One 2009;4:e5624
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The expression of Wnt4 is regulated by estrogen via an estrogen receptor alpha-dependent pathway in rat pituitary GH-producing cells.
Authors: Miyakoshi Et al.
Acta Histochem Cytochem 2009;42:205
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OE stimulates Akt, AMP-activated protein kinase (AMPK) and TBC1D1/4, but not glucose uptake in rat soleus.
Authors: Rogers Et al.
Biochem Biophys Res Commun 2009;382:646
-
The oxysterol receptor LXR inhibits proliferation of human breast cancer cells.
Authors: Vedin Et al.
Cancer Res 2009;30:575
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CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.
Authors: Iorns Et al.
Carcinogenesis 2009;30:1696
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OE-induced estrogen receptor-α trafficking.
Authors: Bondar Et al.
Mol Cell Endocrinol 2009;29:15323
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Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation.
Authors: Zhang Et al.
J Neurosci 2009;29:13823
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Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity.
Authors: Kramár Et al.
Hum Mol Genet 2009;29:12982
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K+-dependent Na+/Ca2+ exchanger 3 is involved in renal active calcium transport and is differentially expressed in the mouse kidney.
Authors: Lee Et al.
Am J Physiol Renal Physiol 2009;297:F371
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A novel mechanism of natural vitamin E tocotrienol activity: involvement of ERbeta signal transduction.
Authors: Comitato Et al.
Am J Physiol Endocrinol Metab 2009;297:E427
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Mutational analysis of progesterone receptor functional domains in stable cell lines delineates sets of genes regulated by different mechanisms.
Authors: Quiles Et al.
Mol Endocrinol 2009;23:809
-
Cell death mechanisms in GT1-7 GnRH cells exposed to polychlorinated biphenyls PCB74, PCB118, and PCB153.
Authors: Dickerson Et al.
Toxicol Appl Pharmacol 2009;237:237
-
Mechanism of the salutary effects of estrogen on kupffer cell phagocytic capacity following trauma-hemorrhage: pivotal role of Akt activation.
Authors: Hsieh Et al.
J Immunol 2009;182:4406
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Differential actions of estrogen and SERMs in regulation of the actin cytoskeleton of endometrial cells.
Authors: Flamini Et al.
Mol Hum Reprod 2009;15:675
-
Soy phytoestrogens are neuroprotective against stroke-like injury in vitro.
Authors: Schreihofer and Redmond
Neuroscience 2009;158:602
-
Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells.
Authors: Leung Et al.
Br J Pharmacol 2009;156:626
-
17Beta-OE at low concentrations acts through distinct pathways in normal versus benign prostatic hyperplasia-derived prostate stromal cells.
Authors: Park Et al.
Endocrinology 2009;150:4594
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Identification of the potent phytoestrogen glycinol in elicited soybean (Glycine max).
Authors: Boue Et al.
Endocrinology 2009;150:2446
-
Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma.
Authors: Belcher Et al.
Endocrinology 2009;150:1112
-
Isoflavone genistein protects human vascular endothelial cells against tumor necrosis factor-alpha-induced apoptosis through the p38beta mitogen-activated protein kinase.
Authors: Si
Apoptosis 2009;14:66
-
Hes-6, an inhibitor of Hes-1, is regulated by 17β-OE and promotes breast cancer cell proliferation.
Authors: Hartman Et al.
Arthritis Res Ther 2009;11:R79
-
Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment.
Authors: McCurley and Callard
BMC Mol Biol 2008;9:102
-
Estrogen determines sex differences in airway responsiveness after allergen exposure.
Authors: Matsubara Et al.
Reprod Sci 2008;38:501
-
Estrogen prevents intestinal inflammation after trauma-hemorrhage via downregulation of angiotensin II and angiotensin II subtype I receptor.
Authors: Chen Et al.
J Mol Endocrinol 2008;295:G1131
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Genomic deletion of estrogen receptors ERalpha and ERbeta does not alter estrogen-mediated inhibition of Ca2+ influx and contraction in murine cardiomyocytes.
Authors: Ullrich Et al.
Am J Physiol Heart Circ Physiol 2008;294:H2421
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Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells.
Authors: Oh Et al.
Mol Cell Biol 2008;28:6580
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Progesterone induction of the 11beta-hydroxysteroid dehydrogenase type 2 promoter in breast cancer cells involves coordinated recruitment of STAT5A and progesterone receptor to a distal enhancer and polymerase tracking.
Authors: Subtil-Rodríguez Et al.
Mol Cell Biol 2008;28:3830
-
Hormonal regulation of BCRP expression in human placental BeWo cells.
Authors: Wang Et al.
Pharm Res 2008;25:444
-
Differential regulation of the inducible nitric oxide synthase gene by estrogen receptors 1 and 2.
Authors: Tsutsumi Et al.
Tissue Eng Part C Methods 2008;199:267
-
The expression and ovarian steroid regulation of endometrial micro-RNAs.
Authors: Toloubeydokhti Et al.
J Exp Clin Cancer Res 2008;15:993
-
Roles of estrogen receptor alpha and beta in modulating urothelial cell proliferation.
Authors: Teng Et al.
Endocr Relat Cancer 2008;15:351
-
Effects of OE and progesterone on the proinflammatory cytokine production by mononuclear cells from patients with chronic hepatitis C.
Authors: Yuan Et al.
World J Gastroenterol 2008;14:2200
-
Estrogen-enhanced gene expression of lipoprotein lipase in heart is antagonized by progesterone.
Authors: Liu Et al.
Endocrinology 2008;149:711
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The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17β-OE on mouse spermatogonial GC-1 cell line.
Authors: Sirianni Et al.
Int J Oncol 2008;149:5043
-
The nutritional flavanone naringenin triggers antiestrogenic effects by regulating estrogen receptor alpha-palmitoylation.
Authors: Galluzzo Et al.
Endocrinology 2008;149:2567
-
Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer.
Authors: Iorns Et al.
Cancer Cell 2008;13:91
-
Genistein, a soy phytoestrogen, upregulates the expression of human endothelial nitric oxide synthase and lowers blood pressure in spontaneously hypertensive rats.
Authors: Si and Liu
J Nutr 2008;138:297
-
Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids.
Authors: Pan Et al.
J Biol Chem 2008;12:227
-
G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells.
Authors: Albanito Et al.
Environ Health Perspect 2008;116:1648
-
Estrogen receptor independent neurotoxic mechanism of bisphenol A, an environmental estrogen.
Authors: Lee Et al.
J Vet Sci 2007;8:27
-
Blockade of estrogen receptors decreases CNS and pituitary prostaglandin synthase expression in fetal sheep.
Authors: Schaub Et al.
FASEB J 2007;87:121
-
Genistein chemoprevention of prostate cancer in TRAMP mice.
Authors: Wang Et al.
J Carcinog 2007;6:3
-
Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators.
Authors: Wittmann Et al.
Cancer Res 2007;67:9549
-
G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-OE and selective GPR30 ligand G-1 in ovarian cancer cells.
Authors: Albanito Et al.
Cancer Res 2007;67:1859
-
NM23-H2, an estrogen receptor β-associated protein, shows diminished expression with progression of atherosclerosis.
Authors: Rayner Et al.
Reprod Sci 2007;292:R743
-
Regulation of GREB1 transcription by estrogen receptor α through a multipartite enhancer spread over 20 kb of upstream flanking sequences.
Authors: Deschênes Et al.
BMC Complement Altern Med 2007;282:17335
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The silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor is required for full estrogen receptor alpha transcriptional activity.
Authors: Peterson Et al.
Mol Cell Biol 2007;27:5933
-
Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death.
Authors: Yao Et al.
J Neurosci 2007;27:1422
-
17β-OE utilizes the estrogen receptor to regulate CD16 expression in monocytes.
Authors: Kramer Et al.
Stroke 2007;279:16
-
Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells.
Authors: Velarde Et al.
Mol Endocrinol 2007;21:2988
-
Modulation of estrogen receptor α protein level and survival function by DBC-1.
Authors: Trauernicht Et al.
Br J Pharmacol 2007;21:1526
-
Neuroprotection by tamox. in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity.
Authors: Zhang Et al.
Exp Neurol 2007;204:819
-
Neuroprotection by estrogen against MPP+-induced DA neuron death is mediated by ERα in primary cultures of mouse mesencephalon.
Authors: Bains Et al.
Biol Reprod 2007;204:767
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Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes.
Authors: Cullen Et al.
Atherosclerosis 2007;195:e125
-
Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells.
Authors: Chang Et al.
Endocrinology 2007;148:4793
-
Exposure to phytoestrogens in the perinatal period affects androgen secretion by testicular Leydig cells in the adult rat.
Authors: Akingbemi Et al.
Endocrinology 2007;148:4475
-
MAPK signaling is critical to OE protection of CA1 neurons in global ischemia.
Authors: Jover-Mengual Et al.
Endocrinology 2007;148:1131
-
Reversal of the estrogen receptor negative phenotype in breast cancer and restoration of antiestrogen response.
Authors: Bayliss Et al.
Clin Cancer Res 2007;13:7029
-
OE-17beta regulates mouse uterine epithelial cell proliferation through Ins-like growth factor 1 signaling.
Authors: Zhu and Pollard
Proc Natl Acad Sci U S A 2007;104:15847
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Additive growth inhibitory effects of ibandr. and antiestrogens in estrogen receptor-positive breast cancer cell lines.
Authors: Journé Et al.
Cancer Res 2006;8:R2
-
Farnesyl-transferase inhibitor R115,777 enhances tamox. inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways.
Authors: Dalenc Et al.
Breast Cancer Res 2006;7:R1159
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Royal jelly stimulates bone formation: physiologic and nutrigenomic studies with mice and cell lines.
Authors: Narita Et al.
Biosci Biotechnol Biochem 2006;70:2508
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17beta-OE, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30.
Authors: Vivacqua Et al.
Mol Pharmacol 2006;70:1414
-
Estrogens, selective estrogen receptor modulators, and a selective estrogen receptor down-regulator inhibit endothelial production of tissue factor pathway inhibitor 1.
Authors: Dahm Et al.
BMC Cardiovasc Disord 2006;6:40
-
Cyclin D1 is necessary for tamoxifen-induced cell cycle progression in human breast cancer cells.
Authors: Kilker and Planas-Silva
Breast Cancer Res 2006;66:11478
-
Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels.
Authors: Wieland Et al.
Am J Physiol Gastrointest Liver Physiol 2006;47:296
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17β-OE inhibits subarachnoid hemorrhage-induced inducible nitric oxide synthase gene expression by interfering with the nuclear factor κ B transactivation.
Authors: Shih Et al.
Proc Natl Acad Sci U S A 2006;37:3025
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Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells.
Authors: Buterin Et al.
Carcinogenesis 2006;27:1567
-
Antiestrogens and the formation of DNA damage in rats: a comparison.
Authors: Kim Et al.
Infect Immun 2006;19:852
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The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes.
Authors: Bowe Et al.
J Endocrinol 2006;191:399
-
Tamoxifen dilates porcine coronary arteries: roles for nitric oxide and ouabain-sensitive mechanisms.
Authors: Leung Et al.
Br J Pharmacol 2006;149:703
-
Activation of Ins-like growth factor I receptor-mediated pathway by ginsenoside Rg1.
Authors: Chen Et al.
Br J Pharmacol 2006;147:542
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Biological role of estrogen receptor β in salivary gland adenocarcinoma cells.
Authors: Ohshiro Et al.
Exp Ther Med 2006;12:5994
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The estrogenic effect of bisphenol A disrupts pancreatic β-cell function in vivo and induces Ins resistance.
Authors: Alonso-Magdalena Et al.
Am J Physiol Gastrointest Liver Physiol 2006;114:106
-
Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamox. sensitivity in resistant breast cancer.
Authors: Wang Et al.
BMC Immunol 2006;10:487
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A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer.
Authors: Xia Et al.
Br J Cancer 2006;103:7795
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An inherent role of microtubule network in the action of nuclear receptor.
Authors: Manavathi Et al.
J Endocrinol 2006;103:15981
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Estrogen receptor signaling protects against immune suppression by UV radiation exposure.
Authors: Widyarini Et al.
Neuroendocrinology 2006;103:12837
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Estrogen receptor alpha pathway is involved in the regulation of Calbindin-D9k in the uterus of immature rats.
Authors: Lee Et al.
Toxicol Sci 2005;84:270
-
Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events.
Authors: Pl?sková Et al.
Toxicol Sci 2005;83:246
-
Membrane estrogen receptor-alpha levels predict estrogen-induced ERK1/2 activation in MCF-7 cells.
Authors: Zivadinovic and Watson
Breast Cancer Res 2005;7:R130
-
Effects of OE on lipopolysaccharide and Pam3Cys stimulation of CCL20/macrophage inflammatory protein 3 α and tumor necrosis factor α production by uterine epithelial cells in culture.
Authors: Crane-Godreau and Wira
Breast Cancer Res Treat 2005;73:4231
-
Gonadal steroids differentially modulate neurotoxicity of HIV and cocaine: testost. and ICI 182,780 sensitive mechanism.
Authors: Kendall Et al.
BMC Neurosci 2005;6:40
-
Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands.
Authors: Islander Et al.
Reprod Nutr Dev 2005;6:16
-
Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels.
Authors: Stirone Et al.
Mol Pharmacol 2005;68:959
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Regulation of endogenous gene expression in human non-small cell lung cancer cells by estrogen receptor ligands.
Authors: Hershberger Et al.
Cancer Cell 2005;65:1598
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The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells.
Authors: Edmunds Et al.
Environ Health Perspect 2005;45:709
-
Soy isoflavones improve endothelial function in spontaneously hypertensive rats in an estrogen-independent manner: role of nitric-oxide synthase, superoxide, and cyclooxygenase metabolites.
Authors: Vera Et al.
J Pharmacol Exp Ther 2005;314:1300
-
Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation.
Authors: Park Et al.
Mol Cell 2005;18:71
-
Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-OE.
Authors: Acconcia Et al.
Mol Biol Cell 2005;16:231
-
Progesterone antagonizes the permissive action of OE on tumor necrosis factor-α-induced apoptosis of anterior pituitary cells.
Authors: Candolfi Et al.
Proc Natl Acad Sci U S A 2005;146:736
-
Firing pattern and rapid modulation of activity by estrogen in primate luteinizing hormone releasing hormone-1 neurons.
Authors: Abe and Terasawa
Endocrinology 2005;146:4312
-
Estrogen modulates endothelial and neuronal nitric oxide synthase expression via an estrogen receptor beta-dependent mechanism in hypothalamic slice cultures.
Authors: Gingerich and Krukoff
Endocrinology 2005;146:2933
-
Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells.
Authors: Ye and Lou
Phytomedicine 2005;12:735
-
Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator.
Authors: Labhart Et al.
Proc Natl Acad Sci U S A 2005;102:1339
-
Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodr. on breast cancer cells.
Authors: Journe Et al.
Breast Cancer Res 2004;91:1703
-
Tamoxifen and the Rafoxifene analog LY117018: their effects on arachidonic acid release from cells in culture and on prostaglandin I2 production by rat liver cells.
Authors: Levine
Proc Natl Acad Sci U S A 2004;4:49
-
Age-related reduction in estrogen receptor-mediated mechanisms of vascular relaxation in female spontaneously hypertensive rats.
Authors: Wynne Et al.
Hypertension 2004;43:405
-
Wnt/β-catenin and estrogen signaling converge in vivo.
Authors: Kouzmenko Et al.
Am J Respir Cell Mol Biol 2004;279:40255
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The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-OE and phytoestrogens in breast cancer cells.
Authors: Maggiolini Et al.
J Biol Chem 2004;279:27008
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Morphological effects of estrogen on cholinergic neurons in vitro involves activation of extracellular signal-regulated kinases.
Authors: Dominguez Et al.
Carcinogenesis 2004;24:982
-
HES-1 inhibits 17β-OE and heregulin-β1-mediated upregulation of E2F-1.
Authors: Hartman Et al.
J Cell Mol Med 2004;23:8826
-
Nuclear Ins receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters.
Authors: Morelli Et al.
Oncogene 2004;23:7517
-
Estrogen receptor beta isoforms exhibit differences in ligand-activated transcriptional activity in an estrogen response element sequence-dependent manner.
Authors: Ramsey Et al.
Endocrinology 2004;145:149
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Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways.
Authors: Bulayeva and Watson
Environ Health Perspect 2004;112:1481
-
Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor α in breast cancer cells.
Authors: Yang Et al.
Oncogene 2004;10:3621
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Regulation of PDGF production and ERK activation by estrogen is associated with TSC2 gene expression.
Authors: Finlay Et al.
Am J Physiol Cell Physiol 2003;285:C409
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The effects of estrogen, its antagonist ICI 182, 780, and IF.-tau on the expression of estrogen receptors and integrin alphaV beta 3 on cycle day 16 in bovine endometrium.
Authors: Kimmins Et al.
Reprod Biol Endocrinol 2003;1:38
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Inhibition of prolactin (PRL)-induced proliferative signals in breast cancer cells by a molecular mimic of phosphorylated PRL, S179D-PRL.
Authors: Schroeder Et al.
Biomol Ther (Seoul) 2003;144:5300
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Environmental estrogens alter early development in Xenopus laevis.
Authors: Bevan Et al.
J Endocrinol 2003;111:488
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Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk.
Authors: Paez-Pereda Et al.
BMC Cancer 2003;100:1034
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Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to OE by aromatase in endothelial cells: implications in atherosclerosis.
Authors: Mukherjee Et al.
Mol Endocrinol 2002;99:4055
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OE reduces F2α-isoprostane production in cultured human endothelial cells.
Authors: Hermenegildo Et al.
Biol Reprod 2002;283:H2644
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Receptor-mediated ethinylOE-induced oxidative DNA damage in rat testicular cells.
Authors: Wellejus and Loft
Proc Natl Acad Sci U S A 2002;16:195
-
17-β-oOE-induced vasorelaxation in vitro is mediated by eNOS through hsp90 and akt/pkb dependent mechanism.
Authors: Bucci Et al.
Drug Metab Dispos 2002;135:1695
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DDT and its metabolites alter gene expression in human uterine cell lines through estrogen receptor-independent mechanisms.
Authors: Frigo Et al.
Environ Health Perspect 2002;110:1239
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Estrogen alters thresholds for B cell apoptosis and activation.
Authors: Grimaldi Et al.
J Clin Invest 2002;109:1625
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The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties.
Authors: Moosmann and Behl
Chem Res Toxicol 1999;96:8867
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Estrogen receptor (ER) modulators each induce distinct conformational changes in ER α and ER β.
Authors: Paige Et al.
J Biomed Sci 1999;96:3999
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OE induces the calcium-dependent translocation of endothelial nitric oxide synthase.
Authors: Goetz Et al.
J Neurosci 1999;96:2788
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High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers.
Authors: Brimmell Et al.
Br J Cancer 1999;81:1042
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