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Ibutilide hemifumarate

Catalog #: 3908 Datasheet
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Ibutilide hemifumarate | CAS No. 122647-32-9 | Ion Channel Modulators
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Description: Blocks IKr, hERG and L-type Ca2+ channels; class III antiarrhythmic

Chemical Name: (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide hemifumarate

Purity: ≥98%

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Biological Activity

Ibutilide hemifumarate is a class III antiarrhythmic. Blocks the rapid component of delayed rectifier K+ current (IKr); also blocks hERG channels and L-type Ca2+ channels. Shown to activate a slow inward Na+ current in guinea pig ventricular cells. Used to terminate atrial fibrillation and atrial flutter; can prolong QT.

Technical Data

M.Wt:
442.61
Formula:
C20H36N2O3S.½C4H4O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in water
Purity:
≥98%
Storage:
Store at RT
CAS No:
122647-32-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Ibutilide.
    Murray
    Circulation, 1998;97:493
  2. Structural determinants of HERG channel block by clofilium and ibut.
    Perry et al.
    Mol.Pharmacol., 2004;66:240
  3. Ionic mechanism of ibut. in human atrium: evidence for a drug-induced Na+ current through nifed. inhibited inward channel.
    Lee and Lee
    J.Pharmacol.Exp.Ther., 1998;286:9

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