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Hyaluronan (Low MW)

Catalog #: GLR001
16 Citations 1 Review Datasheet
Catalog # Availability Size / Price Qty
GLR001
Product Details
Citations (16)
FAQs
Reviews (1)
Summary Product Datasheets Carrier Free Reconstitution Calculator Background Related Research Areas

Hyaluronan (Low MW) Summary

Product Specifications

Source
S. pyogenes fermentation-derived
Predicted Molecular Mass
15 - 40 kDa
SDS-PAGE
20.0 kDa

Product Datasheets

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GLR001

Product Datasheet

GLR001

Formulation White odorless powder
Reconstitution Hyaluronan can be reconstituted in aqueous solutions.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Background: Hyaluronan

Hyaluronan (HA), also known as hyaluronic acid or sodium hyaluronate, is a naturally occurring linear polymer of the repeating disaccharide structure: D-glucuronic acid-beta-1, 3-N-acetylglucosamine-beta-1,4 (1 - 3). It is a glycosaminoglycan (GAG) that is ubiquitously present in the extracellular matrix of all vertebrates and is also present in the capsule of some strains of Streptococci. Unlike other GAGs such as chondroitin sulfate, dermatan sulfate, and heparin sulfate, HA lacks sulfate groups. Except for the covalent binding with the heavy chain of inter-alpha-trypsin inhibitor (2), HA is not covalently associated with other proteins. Mammalian HA is synthesized by one of three distinct HA synthases (HAS1, 2, and 3), which are plasma membrane proteins with multiple transmembrane domains (1 - 4). As UDP-sugar substrates are added, the growing HA polymer continuously translocates across the membrane to the extracellular surface. The three HA synthases differ in their rates of synthesis and produce HA polymers with different chain lengths. Whereas HAS-2 produces high molecular weight (HMW) HA with an average mass of greater than 2000 kDa, HAS-1 and HAS-3 produce HA with a size distribution of 200 - 2000 kDa (4). HA is important for the maintenance of a highly hydrated extracellular matrix in tissues, which is involved in cell adhesion and supports cell migration. HA also exhibits diverse biological functions by interacting with a large number of hyaluronan-binding proteins and cell surface receptors (CD44, LYVE-1) (5). HA biological functions differ depending on the size of HA (3 - 7). Whereas HMW HA (> 500 kDa) is anti-angiogenic, anti-inflammatory, and immunosuppressive, low molecular weight (LMW) HA (10 - 500 kDa) is highly angiogenic and pro-inflammatory. HA oligomers are anti-apoptotic and upregulate heat shock protein expression. HA turns over rapidly in mammals, via the concerted actions of a family of at least 5 hyaluronidases (8).

References
  1. Weigel, P.H. et al. (1997) J. Biol. Chem. 272:13997.
  2. Bost, F. et al. (1998) Eur. J. Biochem. 252:339.
  3. Stern, R. (2004) Eur. J. Cell Biol. 83:317.
  4. Itano, N. and K. Kimata (2002) IUBMB Life 54:195.
  5. Day, A.J. http://www.glycoforum.gr.jp/science/hyaluronan/HA16/HA16E.html.
  6. Powell, J.D. and M.R. Horton (2005) Immunol. Res. 32:207.
  7. Csoka, A.B. et al. (2001) Matrix Biol. 20:499.
  8. Turley, E.A. et al. (2002) J. Biol. Chem. 277:4589.
Alternate Names
Hyaluronan

Citations for Hyaluronan (Low MW)

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

16 Citations: Showing 1 - 10
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  1. Colon impairments and inflammation driven by an altered gut microbiota leads to social behavior deficits rescued by hyaluronic acid and celecoxib
    Authors: Agranyoni, O;Sur, D;Amidror, S;Shidlovsky, N;Bagaev, A;Yissachar, N;Pinhasov, A;Navon-Venezia, S;
    BMC medicine
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo assay
  2. HAPLN1 potentiates peritoneal metastasis in pancreatic cancer
    Authors: L Wiedmann, F De Angelis, N Vaquero-Si, E Donato, E Espinet, I Moll, E Alsina-San, H Bohnenberg, E Fernandez-, R Mülfarth, M Vacca, J Gerwing, LC Conradi, P Ströbel, A Trumpp, C Mogler, A Fischer, J Rodriguez-
    Nature Communications, 2023-04-24;14(1):2353.
    Applications: Bioassay
  3. Multi-modal imaging for uptake of peptide ligand specific for CD44 by hepatocellular carcinoma
    Authors: X Wu, X Meng, TS Chang, S Feng, M Lee, S Jaiswal, EK Choi, L Tran, H Jiang, TD Wang
    Photoacoustics, 2022-04-11;26(0):100355.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. CD44 Can Compensate for IgSF11 Deficiency by Associating with the Scaffold Protein PSD-95 during Osteoclast Differentiation
    Authors: H Kim, N Takegahara, MC Walsh, Y Choi
    Int J Mol Sci, 2020-04-10;21(7):.
    Species: Mouse
    Sample Types: Osteoclast
    Applications: Differentiation, Differentiation
  5. 4-methylumbelliferone inhibits clonogenic potency by suppressing high molecular weight-hyaluronan in fibrosarcoma cells
    Authors: K Hasegawa, R Saga, R Takahashi, R Fukui, M Chiba, K Okumura, E Tsuruga, Y Hosokawa
    Oncol Lett, 2020-02-05;19(4):2801-2808.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse
    Authors: OA Bahri, N Naldaiz-Ga, DC Kennedy, AM Wheatley, A Izeta, KJA McCullagh
    Sci Rep, 2019-11-04;9(1):15964.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Isolation and characterization of myogenic precursor cells from human cremaster muscle
    Authors: N Naldaiz-Ga, M Goicoechea, IM Aragón, V Pérez-Lópe, S Fuertes-Al, B Herrera-Im, A López de M, R de Luna-Di, PM Baptista, MA Fernández, MF Lara, A Izeta
    Sci Rep, 2019-03-05;9(1):3454.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Glycogen debranching enzyme (AGL) is a novel regulator of non-small cell lung cancer growth
    Authors: CS Richmond, D Oldenburg, G Dancik, DR Meier, B Weinhaus, D Theodoresc, S Guin
    Oncotarget, 2018-03-30;9(24):16718-16730.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Induction of systemic inflammation by hyaluronan and hsp70 in women with pre-eclampsia
    Authors: M Romão-Veig, ML Matias, VR Ribeiro, PR Nunes, VT M Borges, JC Peraçoli, MTS Peraçoli
    Cytokine, 2018-02-10;105(0):23-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Modulation of hyaluronan polymer size regulates proliferation of perimysial fibroblasts in thyroid eye disease
    Authors: R Ma, Q Li, Z Wang, Y Yuan, L Gan, J Qian
    Biochem. Biophys. Res. Commun., 2018-02-05;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Hyaluronan and proteoglycan link protein 1 (HAPLN1) activates bortezomib-resistant NF-?B activity and increases drug resistance in multiple myeloma
    Authors: M Huynh, C Pak, S Markovina, NS Callander, KS Chng, SM Wuerzberge, DD Bakshi, JA Kink, P Hematti, C Hope, F Asimakopou, L Rui, S Miyamoto
    J. Biol. Chem., 2017-12-26;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. CD44 and RHAMM are essential for rapid growth of bladder cancer driven by loss of Glycogen Debranching Enzyme (AGL)
    BMC Cancer, 2016-09-05;16(0):713.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Langerhans Cell-Dendritic Cell Cross-Talk via Langerin and Hyaluronic Acid Mediates Antigen Transfer and Cross-Presentation of HIV-1.
    Authors: van den Berg L, Cardinaud S, van der Aar A, Sprokholt J, de Jong M, Zijlstra-Willems E, Moris A, Geijtenbeek T
    J Immunol, 2015-07-13;195(4):1763-73.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Crucial role of hyaluronan in neointimal formation after vascular injury.
    Authors: Kashima Y, Takahashi M, Shiba Y, Itano N, Izawa A, Koyama J, Nakayama J, Taniguchi S, Kimata K, Ikeda U
    PLoS ONE, 2013-03-06;8(3):e58760.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Heterodimeric integrin complexes containing beta1-integrin promote internalization and lethality of anthrax toxin.
    Authors: Martchenko M, Jeong SY, Cohen SN
    Proc. Natl. Acad. Sci. U.S.A., 2010-08-16;107(35):15583-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Identification of a novel chondroitin hydrolase in Caenorhabditis elegans.
    Authors: Kaneiwa T, Yamada S, Mizumoto S, Montano AM, Mitani S, Sugahara K
    J. Biol. Chem., 2008-04-04;283(22):14971-9.
    Species: Human
    Sample Types: Recombinant Protein

FAQs

  1. Does R&D Systems® hyaluronan contain any chondroitin sulfate?

    • No, the hyaluronan is produced by microbial fermentation of Streptococcus pyogenes, which does not make chondroitin sulfate.

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Reviews for Hyaluronan (Low MW)

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Hyaluronan (Low MW)
By Timothy Audam on 10/20/2020
Application: Impact of HA on macrophage phagocytosis and efferocytosis
Reason for Rating: It was quite difficult to get LPS free Low MW HA in the beginning of my study. I found out about LPS free low MW HA from R&D. Gives me confidence in my results