Human VEGFR2/KDR/Flk-1 Fluorescein-conjugated Antibody Summary
Ala20-Glu764
Accession # P35968
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of VEGF R2/KDR/Flk‑1 in HUVEC Human Cells by Flow Cytometry. HUVEC human umbilical vein endothelial cells were stained with Mouse Anti-Human VEGF R2/KDR/Flk-1 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB357F, filled histogram) or isotype control antibody (Catalog # IC002F, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: VEGFR2/KDR/Flk-1
VEGF R2 (KDR/Flk-1), VEGF R1 (Flt-1) and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGF R1, 2, and 3 is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis. Mature VEGF R2 is composed of a 745 aa extracellular domain, a 25 aa transmembrane domain and a 567 aa cytoplasmic domain. In contrast to VEGF R1 which binds both PlGF and VEGF with high affinity, VEGF R2 binds VEGF but not PlGF with high affinity. The recombinant soluble VEGF R2/Fc chimera binds VEGF with high affinity and is a potent VEGF antagonist.
Product Datasheets
Citations for Human VEGFR2/KDR/Flk-1 Fluorescein-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
11
Citations: Showing 1 - 10
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Dysregulated flow‐mediated vasodilatation in the human placenta in fetal growth restriction
Authors: Sarah Jones, Helen Bischof, Ingrid Lang, Gernot Desoye, Sue L. Greenwood, Edward D. Johnstone et al.
The Journal of Physiology
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Intravenous Administration of Allogenic Cell-Derived Microvesicles of Healthy Origins Defend Against Atherosclerotic Cardiovascular Disease Development by a Direct Action on Endothelial Progenitor Cells
Authors: N Alexandru, E Andrei, F Safciuc, E Dragan, AM Balahura, E Badila, A Georgescu
Cells, 2020-02-12;9(2):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Leucocyte and Platelet-rich Fibrin: a carrier of autologous multipotent cells for regenerative medicine
Authors: R Di Liddo, T Bertalot, A Borean, I Pirola, A Argentoni, S Schrenk, C Cenzi, S Capelli, MT Conconi, PP Parnigotto
J. Cell. Mol. Med., 2018-01-05;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Engineered ligand-based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis
Authors: S Kapur, AP Silverman, AZ Ye, N Papo, D Jindal, MS Blumenkran, JR Cochran
Bioeng Transl Med, 2017-02-17;2(1):81-91.
Applications: Flow Cytometry -
Innovative Flow Cytometry Allows Accurate Identification of Rare Circulating Cells Involved in Endothelial Dysfunction
PLoS ONE, 2016-08-25;11(8):e0160153.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Levels of circulating endothelial cells are low in idiopathic pulmonary fibrosis and are further reduced by anti-fibrotic treatments.
Authors: De Biasi S, Cerri S, Bianchini E, Gibellini L, Persiani E, Montanari G, Luppi F, Carbonelli C, Zucchi L, Bocchino M, Zamparelli A, Vancheri C, Sgalla G, Richeldi L, Cossarizza A
BMC Med, 2015-11-09;13(0):277.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Heterochromatin Protein 1 Alpha (HP1alpha: CBX5) is a Key Regulator in Differentiation of Endothelial Progenitor Cells to Endothelial Cells.
Authors: Maeng Y, Kwon J, Kim E, Kwon Y
Stem Cells, 2015-05-01;33(5):1512-22.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property.
Authors: Kishuku M, Nishioka Y, Abe S, Kishi J, Ogino H, Aono Y, Azuma M, Kinoshita K, Batmunkh R, Rentsenhand B, Makino H, Ranjan P, Minakuchi K, Sone S
J. Immunol., 2009-12-15;183(12):8176-85.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Human hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells.
Authors: Xiong YQ, Sun HC, Zhang W
Clin. Cancer Res., 2009-07-28;15(15):4838-46.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Adenosine triphosphate is a critical determinant for VEGFR signal during hypoxia.
Authors: Mamun AA, Hayashi H, Sakima M, Sato M.
Am. J. Physiol., Cell Physiol.
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Involvement of endothelial nitric oxide synthase pathway in IGF?1 protects endothelial progenitor cells against injury from oxidized LDLs
Authors: HJ Wen, GF Liu, LZ Xiao, YG Wu
Mol Med Rep, 2018-11-08;0(0):.
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