Human VEGFR1/Flt-1 Quantikine ELISA Kit Summary
Sample Values
Sample Type | Mean (pg/mL | Range (pg/mL) |
Serum (n=30) | 385 | 294-478 |
EDTA Plasma (n=30) | 292 | 208-391 |
Heparin Plasma (n=30) | 279 | 216-377 |
Saliva (n=10) | 944 | 346-1827 |
Product Summary
Precision
Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma, Saliva
Intra-Assay Precision | Inter-Assay Precision | |||||
---|---|---|---|---|---|---|
Sample | 1 | 2 | 3 | 1 | 2 | 3 |
n | 20 | 20 | 20 | 20 | 20 | 20 |
Mean (pg/mL) | 207 | 610 | 1207 | 207 | 616 | 1205 |
Standard Deviation | 5.16 | 14.9 | 35.6 | 13.9 | 38.9 | 74 |
CV% | 2.5 | 2.4 | 2.9 | 6.7 | 6.3 | 6.1 |
Recovery
The recovery of human VEGF R1 spiked to levels throughout the range of the assay in various matrices was evaluated.
Sample Type | Average % Recovery | Range % |
---|---|---|
Cell Culture Media (n=4) | 99 | 87-110 |
Cell Lysis Buffer (n=4) | 94 | 86-108 |
EDTA Plasma (n=4) | 92 | 84-98 |
Heparin Plasma (n=4) | 89 | 81-96 |
Saliva (n=4) | 109 | 96-124 |
Serum (n=4) | 104 | 93-114 |
Linearity
Scientific Data
Product Datasheets
Preparation and Storage
Background: VEGFR1/Flt-1
VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.
Citations for Human VEGFR1/Flt-1 Quantikine ELISA Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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An examination of the mechanisms driving the therapeutic effects of an AAV expressing a soluble variant of VEGF receptor-1
Authors: Moon, SY;Kim, HJ;Kim, JK;Kim, J;Choi, JS;Won, SY;Park, K;Lee, SHS;
PloS one
Species: Human
Sample Types: Cell Culture Supernates
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Neuropilin-1 and placental growth factor as prognostic factors in metastatic breast cancer
Authors: Mäenpää, N;Tiainen, L;Hämäläinen, M;Luukkaala, T;Tanner, M;Lahdenperä, O;Vihinen, P;Karihtala, P;Kellokumpu-Lehtinen, PL;Moilanen, E;Jukkola, A;
BMC cancer
Species: Human
Sample Types: Plasma
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Mechanism matters: mortality and endothelial cell damage marker differences between blunt and penetrating traumatic injuries across three prehospital clinical trials
Authors: Donohue, JK;Gruen, DS;Iyanna, N;Lorence, JM;Brown, JB;Guyette, FX;Daley, BJ;Eastridge, BJ;Miller, RS;Nirula, R;Harbrecht, BG;Claridge, JA;Phelan, HA;Vercruysse, GA;O'Keeffe, T;Joseph, B;Neal, MD;Billiar, TR;Sperry, JL;
Scientific reports
Species: Human
Sample Types: Plasma
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An Examination of the Effect of Aspirin and Salicylic Acid on Soluble Fms-like Tyrosine Kinase-1 Release from Human Placental Trophoblasts
Authors: Zhao, J;Duan, R;Sun, J;Chow, RP;Lyons, TJ;Yu, JY;
Cells
Species: Human
Sample Types: Cell Culture Supernates
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A Novel Dual-Function Redox Modulator Relieves Oxidative Stress and Anti-Angiogenic Response in Placental Villus Explant Exposed to Hypoxia-Relevance for Preeclampsia Therapy
Authors: Pintye, D;Sziva, RE;Mastyugin, M;Young, BC;Jacas, S;Török, M;Salahuddin, S;Jagtap, P;Southan, GJ;Zsengellér, ZK;
Biology
Species: Human
Sample Types: Cell Culture Supernates
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sFlt-1-enriched exosomes induced endothelial cell dysfunction and a preeclampsia-like phenotype in mice
Authors: X Huang, L Jia, Y Jia, X Xu, R Wang, M Wei, H Li, H Peng, Y Wei, Q He, K Wang
Cytokine, 2023-04-14;166(0):156190.
Species: Human, Mouse
Sample Types: Cell Culture Supernates, Serum
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Interaction between PD-L1 and soluble VEGFR1 in glioblastoma-educated macrophages
Authors: X Liu, Z Li, J Sun, Z Zhang, W Li
BMC Cancer, 2023-03-20;23(1):259.
Species: Human
Sample Types: Serum
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Alterations in Antioxidant Micronutrient Concentrations in Placental Tissue, Maternal Blood and Urine and the Fetal Circulation in Pre-eclampsia
Authors: LO Kurlak, PJ Scaife, LV Briggs, F Broughton, DS Gardner, HD Mistry
International Journal of Molecular Sciences, 2023-02-10;24(4):.
Species: Human
Sample Types: Plasma
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Human umbilical cord mesenchymal stem cell-derived extracellular vesicles loaded with TFCP2 activate Wnt/?-catenin signaling to alleviate preeclampsia
Authors: Yang, Z;Jia, X;Deng, Q;Luo, M;Hou, Y;Yue, J;Mei, J;Shan, N;Wu, Z;
International immunopharmacology
Species: Human
Sample Types: Serum
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Similar Pro- and Antiangiogenic Profiles Close to Delivery in Different Clinical Presentations of Two Pregnancy Syndromes: Preeclampsia and Fetal Growth Restriction
Authors: W Dymara-Kon, M Laskowska, E Grywalska, A Hymos, A B?a?ewicz, B Leszczy?sk
International Journal of Molecular Sciences, 2023-01-04;24(2):.
Species: Human
Sample Types: Serum
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Cholecalciferol supplementation and angiogenic markers in chronic kidney disease
Authors: J Kaur, K Kamboj, AK Yadav, P Kaur, V Kumar, V Jha
PLoS ONE, 2022-06-03;17(6):e0268946.
Species: Human
Sample Types: Serum
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Placental lesions and differential expression of pro-and anti-angiogenic growth mediators and oxidative DNA damage marker in placentae of Ghanaian suboptimal and optimal health status pregnant women who later developed preeclampsia
Authors: EO Anto, DA Coall, EA Asiamah, OO Afriyie, O Addai-Mens, YA Wiafe, W Owiredu, C Obirikoran, ME Annani-Ako, NA Titiloye, E Adua, E Acheampong, EA Adu, S Opoku, AO Anto, A Tawiah, Y Wang, W Wang
PLoS ONE, 2022-03-21;17(3):e0265717.
Species: Human
Sample Types: Plasma
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Hematobiochemical variability and predictors of new-onset and persistent postpartum preeclampsia
Authors: LA Fondjo, B Amoah, JJ Annan, EA Adu-Gyamfi, EA Asamaoh
Scientific Reports, 2022-03-04;12(1):3583.
Species: Human
Sample Types: Serum
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Effect of Placenta-Derived Mesenchymal Stromal Cells Conditioned Media on an LPS-Induced Mouse Model of Preeclampsia
Authors: AM Nuzzo, L Moretti, P Mele, T Todros, C Eva, A Rolfo
International Journal of Molecular Sciences, 2022-01-31;23(3):.
Species: Human
Sample Types: Protein
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Impact of Chronic Kidney Disease on the Associations of Cardiovascular Biomarkers With Adverse Outcomes in Patients With Suspected or Known Coronary Artery Disease: The EXCEED-J Study
Authors: H Wada, T Shinozaki, M Suzuki, S Sakagami, Y Ajiro, J Funada, M Matsuda, M Shimizu, T Takenaka, Y Morita, K Yonezawa, H Matsubara, Y Ono, T Nakamura, K Fujimoto, A Ninomiya, T Kato, T Unoki, D Takagi, K Wada, M Wada, M Iguchi, H Yamakage, T Kusakabe, A Yasoda, A Shimatsu, K Kotani, N Satoh-Asah, M Abe, M Akao, K Hasegawa, EXCEED?J S
Journal of the American Heart Association, 2022-01-20;11(3):e023464.
Species: Human
Sample Types: Serum
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Spatial and temporal VEGF receptor intracellular trafficking in microvascular and macrovascular endothelial cells
Authors: JAF Silva, X Qi, MB Grant, ME Boulton
Scientific Reports, 2021-08-30;11(1):17400.
Species: Human
Sample Types: Nuclear Extract
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FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells
Authors: T Jia, T Jacquet, F Dalonneau, P Coudert, E Vaganay, C Exbrayat-H, J Vollaire, V Josserand, F Ruggiero, JL Coll, B Eymin
Bmc Biology, 2021-08-25;19(1):173.
Species: Human
Sample Types: Cell Culture Supernates
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Circulating levels of angiogenic factors and their association with preeclampsia among pregnant women at Mulago National Referral Hospital in Uganda
Authors: S Nabweyambo, OJ Sande, N McGovern, F Bwanga, A Ssekagiri, A Keesiga, M Adroma, R Wasswa, M Atuheirwe, J Namugenyi, B Castelnuov, A Nakimuli
PLoS ONE, 2021-05-19;16(5):e0251227.
Species: Human
Sample Types: Plasma
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Circulating miRNAs Associated with Dysregulated Vascular and Trophoblast Function as Target-Based Diagnostic Biomarkers for Preeclampsia
Authors: S Kim, M Park, JY Kim, T Kim, JY Hwang, KS Ha, MH Won, S Ryoo, YG Kwon, YM Kim
Cells, 2020-08-31;9(9):.
Species: Human
Sample Types: Serum
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Divergent Impact of Breast Cancer Laterality on Clinicopathological, Angiogenic, and Hemostatic Profiles: A Potential Role of Tumor Localization in Future Outcomes
Authors: RC Barbara, R Piotr, B Kornel, Z El?bieta, R Danuta, N Eduardo
J Clin Med, 2020-06-02;9(6):.
Species: Human
Sample Types: Plasma
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Sleep-disordered breathing does not impact maternal outcomes in women with hypertensive disorders of pregnancy
Authors: DL Wilson, ME Howard, AM Fung, FJ O'Donoghue, M Barnes, M Lappas, SP Walker
PLoS ONE, 2020-04-27;15(4):e0232287.
Species: Human
Sample Types: Plasma
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Hydroxychloroquine Mitigates the Production of 8-Isoprostane and Improves Vascular Dysfunction: Implications for Treating Preeclampsia
Authors: RA Rahman, P Murthi, H Singh, S Gurungsing, B Leaw, JC Mockler, R Lim, EM Wallace
Int J Mol Sci, 2020-04-03;21(7):.
Species: Human
Sample Types: Placenta
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Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia
Authors: P Nikuei, M Rajaei, N Roozbeh, F Mohseni, F Poordarvis, M Azad, S Haidari
BMC Pregnancy Childbirth, 2020-02-07;20(1):80.
Species: Human
Sample Types: Serum
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Retina transduction by rAAV2 after intravitreal injection: comparison between mouse and rat
Authors: MS Dias, VG Araujo, T Vasconcelo, Q Li, WW Hauswirth, R Linden, H Petrs-Silv
Gene Ther., 2019-09-27;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
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Systemic Inflammation Precedes Microalbuminuria in Diabetes
Authors: FG Scurt, J Menne, S Brandt, A Bernhardt, PR Mertens, H Haller, C Chatzikyrk
Kidney Int Rep, 2019-06-21;4(10):1373-1386.
Species: Human
Sample Types: Serum
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Anti-angiogenic efficacy in invasive breast carcinoma patients depends on clinicopathological determinants
Authors: E Zarychta, P Rhone, K Bielawski, M Michalska, D Ro??, B Ruszkowska
Adv Med Sci, 2019-02-26;64(2):216-223.
Species: Human
Sample Types: Plasma
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Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection
Authors: HW Unger, AP Hansa, C Buffet, W Hasang, A Teo, L Randall, M Ome-Kaius, S Karl, AA Anuan, JG Beeson, I Mueller, SJ Stock, SJ Rogerson
Sci Rep, 2019-02-19;9(1):2260.
Species: Human
Sample Types: Plasma
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Angiogenic Properties of Menstrual Stem Cells Are Impaired in Women with a History of Preeclampsia
Authors: M Varas-Godo, S Acuña-Gall, S Venegas-Du, C Hill, A Caceres-Ve, O Realini, LJ Monteiro, G Zavala, M Khoury, R Romero, G Rice, SE Illanes
Stem Cells Int, 2019-01-27;2019(0):1916542.
Species: Human
Sample Types: Cell Culture Supernates
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A VEGF-A/SOX2/SRSF2 network controls VEGFR1 pre-mRNA alternative splicing in lung carcinoma cells
Authors: C Abou Fayca, S Gazzeri, B Eymin
Sci Rep, 2019-01-23;9(1):336.
Species: Human
Sample Types: Cell Culture Supernates
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ELABELA concentration is not decreased in maternal plasma before the onset of preeclampsia
Authors: P Villie, G Lefevre, R Arrestier, A Rousseau, N Berkane, A Hertig
Am. J. Obstet. Gynecol., 2018-12-18;220(3):284-285.
Species: Human
Sample Types: Plasma
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Intravitreal Injection of AAV Expressing Soluble VEGF Receptor-1 Variant Induces Anti-VEGF Activity and Suppresses Choroidal Neovascularization
Authors: SHS Lee, HJ Kim, OK Shin, JS Choi, J Kim, YH Cho, J Ha, TK Park, JY Lee, K Park, H Lee
Invest. Ophthalmol. Vis. Sci., 2018-11-01;59(13):5398-5407.
Species: Human
Sample Types: Cell Lysates
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Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice
Authors: JA Sandgren, G Deng, DW Linggonego, SM Scroggins, KJ Perschbach, AR Nair, TE Nishimura, SY Zhang, LN Agbor, J Wu, HL Keen, MC Naber, NA Pearson, KA Zimmerman, RM Weiss, NC Bowdler, YM Usachev, DA Santillan, MJ Potthoff, GL Pierce, KN Gibson-Cor, CD Sigmund, MK Santillan, JL Grobe
JCI Insight, 2018-10-04;3(19):.
Species: Mouse
Sample Types: Tissue Homogenates
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Rationally designed AAV2 and AAVrh8R capsids provide improved transduction in the retina and brain
Authors: JA Sullivan, LM Stanek, MJ Lukason, J Bu, SR Osmond, EA Barry, CR O'Riordan, LS Shihabuddi, SH Cheng, A Scaria
Gene Ther., 2018-05-22;0(0):.
Species: Mouse, Rabbit
Sample Types: Tissue Homogenates, Vitreous Humor
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Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts
Authors: GS Stødle, GB Silva, LH Tangerås, LM Gierman, I Nervik, UE Dahlberg, C Sun, MH Aune, LCV Thomsen, L Bjørge, AC Iversen
Clin. Exp. Immunol., 2018-04-23;0(0):.
Species: Human
Sample Types: Serum
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Arginase controls soluble vascular endothelial growth factor receptor 1 (sFlt1) to maintain pregnancy homeostasis
Authors: H Tanaka, K Kumasawa, A Kakigano, K Mimura, M Endo, T Tomimatsu, T Kimura
Biochem. Biophys. Res. Commun., 2018-03-24;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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LIFR increases the release of sEng via the up-regulation of MMP14 expression in PE
Authors: H Li, J Yao, X Chang, J Wu, T Duan, K Wang
Reproduction, 2018-01-23;0(0):.
Species: Human
Sample Types: Plasma
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Corneal Mesenchymal Stromal Cells Are Directly Antiangiogenic via PEDF and sFLT-1
Authors: M Eslani, I Putra, X Shen, J Hamouie, N Afsharkham, S Besharat, MI Rosenblatt, R Dana, P Hematti, AR Djalilian
Invest. Ophthalmol. Vis. Sci., 2017-10-01;58(12):5507-5517.
Species: Human
Sample Types: Cell Culture Supernates
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Endothelial Dysfunction in Severe Preeclampsia is Mediated by Soluble Factors, Rather than Extracellular Vesicles
Authors: M O'Brien, D Baczyk, JC Kingdom
Sci Rep, 2017-07-19;7(1):5887.
Species: Human
Sample Types: Tissue Culture Supernates
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Household air pollution and angiogenic factors in pregnant Nigerian women: A randomized controlled ethanol cookstove intervention
Authors: A Dutta, K Brito, G Khramstova, A Mueller, S Chinthala, D Alexander, D Adu, T Ibigbami, J Olamijulo, A Odetunde, K Adigun, L Pruitt, O Olopade, O Ojengbede, S Rana, CO Olopade
Sci. Total Environ., 2017-05-29;599(0):2175-2181.
Species: Human
Sample Types: Plasma
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Synthetic Receptors Induce Anti Angiogenic and Stress Signaling on Human First Trimester Cytotrophoblast Cells
Authors: AF Pantho, M Price, AZ Ashraf, U Wajid, ME Khansari, A Jahan, SH Afroze, MM Rhaman, CR Johnson, TJ Kuehl, MA Hossain, MN Uddin
Int J Environ Res Public Health, 2017-05-11;14(5):.
Species: Human
Sample Types: Cell Culture Supernates
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The anti-angiogenic role of soluble-form VEGF receptor in malignant gliomas
Authors: Shingo Takano
Int. J. Oncol, 2016-12-19;0(0):.
Species: Human
Sample Types: Tissue Homogenates
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Low grade inflammation inhibits VEGF induced HUVECs migration in p53 dependent manner
Authors: Sushil Panta
Biochem. Biophys. Res. Commun, 2016-12-18;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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Spectrum of Factors Triggering Endothelial Dysfunction in PIH
Authors: VS Jammalamad, P Abraham
J Clin Diagn Res, 2016-12-01;10(12):BC14-BC17.
Species: Human
Sample Types: Serum
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Albuminuria Is Associated with Endothelial Dysfunction and Elevated Plasma Endothelin-1 in Sickle Cell Anemia
PLoS ONE, 2016-09-26;11(9):e0162652.
Species: Human
Sample Types: Plasma
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Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia
Authors: Ingrid C Weel
PLoS ONE, 2016-06-17;11(6):e0157584.
Species: Human
Sample Types: Tissue Homogenates
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Inhibition of placental growth factor in renal cell carcinoma.
Authors: Bessho H, Wong B, Huang D, Siew E, Huang D, Tan J, Ong C, Tan S, Matsumoto K, Iwamura M, Teh B
Anticancer Res, 2015-01-01;35(1):531-41.
Species: Human
Sample Types: Cell Culture Supernates
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Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer.
Authors: Sallinen H, Heikura T, Koponen J, Kosma V, Heinonen S, Yla-Herttuala S, Anttila M
BMC Cancer, 2014-09-23;14(0):696.
Species: Human
Sample Types: Serum
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FLT1 genetic variation predisposes to neovascular AMD in ethnically diverse populations and alters systemic FLT1 expression.
Authors: Owen, Leah A, Morrison, Margaux, Ahn, Jeeyun, Woo, Se Joon, Sato, Hajime, Robinson, Rosann, Morgan, Denise J, Zacharaki, Fani, Simeonova, Marina, Uehara, Hironori, Chakravarthy, Usha, Hogg, Ruth E, Ambati, Balamura, Kotoula, Maria, Baehr, Wolfgang, Haider, Neena B, Silvestri, Giuliana, Miller, Joan W, Tsironi, Evangeli, Farrer, Lindsay, Kim, Ivana K, Park, Kyu Hyun, DeAngelis, Margaret
Invest Ophthalmol Vis Sci, 2014-05-08;55(6):3543-54.
Species: Human
Sample Types: Serum
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Persistent urinary podocyte loss following preeclampsia may reflect subclinical renal injury.
Authors: White W, Garrett A, Craici I, Wagner S, Fitz-Gibbon P, Butters K, Brost B, Rose C, Grande J, Garovic V
PLoS ONE, 2014-03-24;9(3):e92693.
Species: Human
Sample Types: Serum
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Analysis of plasma cytokines and angiogenic factors in patients with pretreated urothelial cancer receiving Pazopanib: the role of circulating interleukin-8 to enhance the prognostic accuracy.
Authors: Necchi A, Pennati M, Zaffaroni N, Landoni E, Giannatempo P, Raggi D, Schwartz L, Morosi C, Crippa F, Fare E, Nicolai N, Lanocita R, Sava T, Sacco C, Messina C, Ortega C, De Braud F, Salvioni R, Daidone M, Gianni A, Mariani L
Br J Cancer, 2013-11-14;110(1):26-33.
Species: Human
Sample Types: Plasma
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Integrating multiple 'omics' analyses identifies serological protein biomarkers for preeclampsia.
Authors: Liu, Linda Y, Yang, Ting, Ji, Jun, Wen, Qiaojun, Morgan, Alexande, Jin, Bo, Chen, Gongxing, Lyell, Deirdre, Stevenson, David K, Ling, Xuefeng, Butte, Atul J
BMC Med, 2013-11-06;11(0):236.
Species: Human
Sample Types: Serum
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Placental growth factor and soluble Fms-like tyrosine kinase 1 in diabetic pregnancy: A possible relation to distal villous immaturity.
Authors: El-Tarhouny S, Almasry S, Elfayomy A, Baghdadi H, Habib F
Histol Histopathol, 2013-08-13;29(2):259-72.
Species: Human
Sample Types: Serum
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Fcgamma receptor-induced soluble vascular endothelial growth factor receptor-1 (VEGFR-1) production inhibits angiogenesis and enhances efficacy of anti-tumor antibodies.
Authors: Justiniano S, Elavazhagan S, Fatehchand K, Shah P, Mehta P, Roda J, Mo X, Cheney C, Hertlein E, Eubank T, Marsh C, Muthusamy N, Butchar J, Byrd J, Tridandapani S
J Biol Chem, 2013-07-31;288(37):26800-9.
Species: Human
Sample Types: Cell Culture Supernates
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Advanced oxidation protein products enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts: a possible link between oxidative stress and preeclampsia.
Authors: Huang Q, Wang S, Zhang M, Huang L, Tian J, Yu Y, Wang Z, Zhong M
Placenta, 2013-07-27;34(10):949-52.
Species: Human
Sample Types: Cell Culture Supernates
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A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment.
Authors: Suzuki T, Shimada H, Makizako H, Doi T, Yoshida D, Ito K, Shimokata H, Washimi Y, Endo H, Kato T
PLoS ONE, 2013-04-09;8(4):e61483.
Species: Human
Sample Types: Serum
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Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin and paclitaxel containing sequential radiotherapy.
Authors: Braicu E, Fotopoulou C, Chekerov R, Richter R, Blohmer J, Kummel S, Stamatian F, Yalcinkaya I, Mentze M, Lichtenegger W, Sehouli J
Cytokine, 2013-02-14;61(3):755-8.
Species: Human
Sample Types: Serum
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Cardiac angiogenic imbalance leads to peripartum cardiomyopathy.
Authors: Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z
Nature, 2012-05-09;485(7398):333-8.
Species: Human
Sample Types: Plasma
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In vitro vascular tube formation testing as a tool for treatment individualisation in patients with cervical cancer.
Authors: Landt S, Heidecke H, Korlach S, Reuter C, Schwidde I, Barinoff J, Thill M, Sehouli J, Kummel S
Anticancer Res., 2011-08-01;31(8):2609-15.
Species: Human
Sample Types: Serum
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Prognostic significance of angiogenic factors in uterine cervical cancer.
Authors: Landt S, Wehling M, Heidecke H, Jeschke S, Korlach S, Stoblen F, Schmid P, Blohmer JU, Lichtenegger W, Sehouli J, Kummel S
Anticancer Res., 2011-08-01;31(8):2589-95.
Species: Human
Sample Types: Serum
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Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer.
Authors: Rahbari NN, Schmidt T, Falk CS, Hinz U, Herber M, Bork U, Buchler MW, Weitz J, Koch M
BMC Cancer, 2011-07-05;11(0):286.
Species: Human
Sample Types: Serum
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Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a children's oncology group study.
Authors: Dubois SG, Shusterman S, Ingle AM, Ahern CH, Reid JM, Wu B, Baruchel S, Glade-Bender J, Ivy P, Grier HE, Adamson PC, Blaney SM
Clin. Cancer Res., 2011-06-20;17(15):5113-22.
Species: Human
Sample Types: Plasma
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Effect of smoking on circulating angiogenic factors in high risk pregnancies.
Authors: Jeyabalan A, Powers RW, Clifton RG, Van Dorsten P, Hauth JC, Klebanoff MA, Lindheimer MD, Sibai B, Landon M, Miodovnik M, Caritis S, Roberts JM, Kuller J, Cotroneo M, Kamon T, Mercer B, Ramsey R, Paul R, Rabello Y, McCart D, Mueller E, Goldenberg R, Copper R, Sorokin Y, Norman G, Millinder A, Christmas JT, McCoy S, Elder S, Elder N, Carter B, Pemberton V, Thurnau G, Meier A, Minton V, Meis P, Swain M, Moawad AH, Jones P, Iams JD, Meadows S, Brenner S, Collins B, Newman RB, Carter SG, Romero R, Sabo V, Thom E, Bain RP, MacPherson C, Johnson D, Fischer ML, McNellis D, Spong C, Catz C, Yaffe S
PLoS ONE, 2010-10-12;5(10):e13270.
Species: Human
Sample Types: Serum
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Soluble fms-Like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies.
Authors: Powers RW, Jeyabalan A, Clifton RG
PLoS ONE, 2010-10-11;5(10):e13263.
Species: Human
Sample Types: Serum
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Periodic assessment of plasma sFlt-1 and PlGF concentrations and its association with placental morphometry in gestational hypertension (GH) - a prospective follow-up study.
Authors: Jeevaratnam K, Nadarajah VD, Judson JP
BMC Pregnancy Childbirth, 2010-09-28;10(0):58.
Species: Human
Sample Types: Plasma
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Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice.
Authors: Kosugi T, Nakayama T, Li Q, Chiodo VA, Zhang L, Campbell-Thompson M, Grant M, Croker BP, Nakagawa T
Am. J. Physiol. Renal Physiol., 2009-12-16;298(3):F609-16.
Species: Human
Sample Types: Urine
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Pre-eclampsia, soluble fms-like tyrosine kinase 1, and the risk of reduced thyroid function: nested case-control and population based study.
Authors: Levine RJ, Vatten LJ, Horowitz GL
BMJ, 2009-11-17;339(0):b4336.
Species: Human
Sample Types: Serum
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An automated method for the determination of the sFlt-1/PIGF ratio in the assessment of preeclampsia.
Authors: Verlohren S, Galindo A, Schlembach D, Zeisler H, Herraiz I, Moertl MG, Pape J, Dudenhausen JW, Denk B, Stepan H
Am. J. Obstet. Gynecol., 2009-10-21;202(2):161.e1-161.e1.
Species: Human
Sample Types: Serum
-
Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis.
Authors: Bourlev V, Iljasova N, Adamyan L, Larsson A, Olovsson M
Fertil. Steril., 2009-03-25;94(1):52-7.
Species: Human
Sample Types: Serum
-
Are plasma VEGF and its soluble receptor sFlt-1 atherogenic risk factors? Cross-sectional data from the SAPHIR study.
Authors: Sandhofer A, Tatarczyk T, Kirchmair R, Iglseder B, Paulweber B, Patsch JR, Schratzberger P
Atherosclerosis, 2009-02-03;206(1):265-9.
Species: Human
Sample Types: Plasma
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Antiangiogenic gene therapy with soluble VEGFR-1, -2, and -3 reduces the growth of solid human ovarian carcinoma in mice.
Authors: Sallinen H, Anttila M, Narvainen J, Koponen J, Hamalainen K, Kholova I, Heikura T, Toivanen P, Kosma VM, Heinonen S, Alitalo K, Yla-Herttuala S
Mol. Ther., 2008-12-02;17(2):278-84.
Species: Human
Sample Types: Plasma
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Natural selection of FLT1 alleles and their association with malaria resistance in utero.
Authors: Muehlenbachs A, Fried M, Lachowitzer J, Mutabingwa TK, Duffy PE
Proc. Natl. Acad. Sci. U.S.A., 2008-09-08;105(38):14488-91.
Species: Human
Sample Types: Cell Culture Supernates, Plasma
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Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease.
Authors: Findley CM, Mitchell RG, Duscha BD, Annex BH, Kontos CD
J. Am. Coll. Cardiol., 2008-07-29;52(5):387-93.
Species: Human
Sample Types: Plasma
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Cigarette smoke exposure and angiogenic factors in pregnancy and preeclampsia.
Authors: Jeyabalan A, Powers RW, Durica AR, Harger GF, Roberts JM, Ness RB
Am. J. Hypertens., 2008-06-19;21(8):943-7.
Species: Human
Sample Types: Plasma
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Regulation of vascular endothelial growth factor-A and its soluble receptor sFlt-1 by luteinizing hormone in vivo: implication for ovarian follicle angiogenesis.
Authors: Gutman G, Barak V, Maslovitz S, Amit A, Lessing JB, Geva E
Fertil. Steril., 2008-03-17;89(4):922-6.
Species: Human
Sample Types: Serum
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Angiogenesis markers (VEGF, soluble receptor of VEGF and angiopoietin-1) in very early arthritis and their association with inflammation and joint destruction.
Authors: Clavel G, Bessis N, Lemeiter D, Fardellone P, Mejjad O, Menard JF, Pouplin S, Boumier P, Vittecoq O, Le Loet X, Boissier MC
Clin. Immunol., 2007-06-08;124(2):158-64.
Species: Human
Sample Types: Serum
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Significant decrease in angiopoietin-1 and angiopoietin-2 after radical prostatectomy in prostate cancer patients.
Authors: Caine GJ, Ryan P, Lip GY, Blann AD
Cancer Lett., 2007-01-19;251(2):296-301.
Species: Human
Sample Types: Plasma
-
Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction.
Authors: Wallner W, Sengenberger R, Strick R, Strissel PL, Meurer B, Beckmann MW, Schlembach D
Clin. Sci., 2007-01-01;112(1):51-7.
Species: Human
Sample Types: Serum
-
Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.
Authors: Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R, Karumanchi SA
N. Engl. J. Med., 2006-09-07;355(10):992-1005.
Species: Human
Sample Types: Serum
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Changes in plasma vascular endothelial growth factor, angiopoietins, and their receptors following surgery for breast cancer.
Authors: Caine GJ, Stonelake PS, Lip GY, Blann AD
Cancer Lett., 2006-08-07;248(1):131-6.
Species: Human
Sample Types: Plasma
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Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis.
Authors: Masuyama H, Suwaki N, Nakatsukasa H, Masumoto A, Tateishi Y, Hiramatrsu Y
Am. J. Obstet. Gynecol., 2006-02-01;194(2):551-6.
Species: Human
Sample Types: Serum
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Phase I clinical and pharmacokinetic study of PTK/ZK, a multiple VEGF receptor inhibitor, in patients with liver metastases from solid tumours.
Authors: Mross K, Drevs J, Muller M, Medinger M, Marme D, Hennig J, Morgan B, Lebwohl D, Masson E, Ho YY, Gunther C, Laurent D, Unger C
Eur. J. Cancer, 2005-06-01;41(9):1291-9.
Species: Human
Sample Types: Serum
-
Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia.
Authors: Buhimschi CS, Norwitz ER, Funai E, Richman S, Guller S, Lockwood CJ, Buhimschi IA
Am. J. Obstet. Gynecol., 2005-03-01;192(3):734-41.
Species: Human
Sample Types: Urine
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Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta.
Authors: Li H, Gu B, Zhang Y, Lewis DF, Wang Y
Placenta, 2005-02-01;26(2):210-7.
Species: Human
Sample Types: Cell Culture Supernates
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Urinary placental growth factor and risk of preeclampsia.
Authors: Levine RJ, Thadhani R, Qian C, Lam C, Lim KH, Yu KF, Blink AL, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA
JAMA, 2005-01-05;293(1):77-85.
Species: Human
Sample Types: Urine
-
GM-CSF induces expression of soluble VEGF receptor-1 from human monocytes and inhibits angiogenesis in mice.
Authors: Eubank TD, Roberts R, Galloway M, Wang Y, Cohn DE, Marsh CB
Immunity, 2004-12-01;21(6):831-42.
Species: Human
Sample Types: Cell Culture Supernates
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Circulating angiogenic factors and the risk of preeclampsia.
Authors: Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA
N. Engl. J. Med., 2004-02-05;350(7):672-83.
Species: Human
Sample Types: Serum
-
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.
Authors: Maynard SE, Min JY, Merchan J, Lim KH, Mondal S, Stillman IE, Epstein FH, Karumanchi SA
J. Clin. Invest., 2003-03-01;111(5):649-58.
Species: Human
Sample Types: Serum
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