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Human VEGFR1/Flt-1 Antibody

Catalog #: AF321
73 Citations 5 Reviews Datasheet
Catalog # Availability Size / Price Qty
AF321
AF321-SP
VEGFR1/Flt‑1 in Human Breast Cancer Tissue.
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Product Details
Citations (73)
FAQs
Supplemental Products
Reviews (5)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human VEGFR1/Flt-1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human VEGFR1/Flt-1 in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human VEGFR1/Flt-1
Ser27-His687
Accession # NP_001153392
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human VEGFR1/Flt‑1 Fc Chimera (Catalog # 321-FL)
Flow Cytometry
0.25 µg/106 cells
HUVEC human umbilical vein endothelial cells
Immunohistochemistry
5-15 µg/mL
See below
Blockade of Receptor-ligand Interaction
In a functional ELISA, 1-4 µg/mL of this antibody will block 50% of the binding of 2 ng/mL of Recombinant Human PlGF (Catalog # 264-PG) to immobilized Recombinant Human VEGFR1/Flt-1 Fc Chimera (Catalog # 321-FL) coated at 1 µg/mL (100 µL/well). At 30 μg/mL, this antibody will block >90% of the binding.
 
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry VEGFR1/Flt-1 antibody in Human Breast Cancer Tissue by Immunohistochemistry (IHC-P). View Larger

VEGFR1/Flt‑1 in Human Breast Cancer Tissue. VEGFR1/Flt‑1 was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using 15 µg/mL Human VEGFR1/Flt‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF321) overnight at 4 °C. Tissue was stained (red) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Immunohistochemistry VEGFR1/Flt-1 antibody in Human Ovarian Cancer Tissue by Immunohistochemistry (IHC-P). View Larger

VEGFR1/Flt‑1 in Human Ovarian Cancer Tissue. VEGFR1/Flt-1 was detected in immersion fixed paraffin-embedded sections of human ovarian cancer tissue using Human VEGFR1/Flt-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF321) at 3 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Western Blot Detection of Human VEGFR1/Flt-1 by Western Blot View Larger

Detection of Human VEGFR1/Flt-1 by Western Blot Exogenous VEGF165 suppresses RASSF1A expression in normal epithelial and endothelial cells. Metastatic colon cancer cells (mCRC, (A) T84 and (B) Colo 205) were stimulated with VEGF165 as indicated before and cell metabolism was performed by MTT assay for 6 h (black dash), 24 h (green) and 48 h (pink). Immortalized benign protate ((C) RWPE1), human bronchial epithelial cells ((D) HBEpc), immortalized human breast epithelial cells ((E) MCF-10A), endothelial cells (F, EC) were stimulated with or without VEGF165 (12.5 and 25 ng/mL) for 24 h. Cell lysates were monitored by Western blot for p-VEGFR1, p-VEGFR2, RASSF1A, and GAPDH as indicated. Immunoblot was quantified by scanning densitometry and normalized against GAPDH expression for RWPE1 (G), HBEpc (H), MCF 10A (I) and EC (lower panel of (F)). Results are from three independent experiments and statistical significance was determined using one way-ANOVA followed Bonferroni test. (* p < 0.05, ** p < 0.01, *** p < 0.001). Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/30744076), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Human VEGFR1/Flt-1 by Western Blot View Larger

Detection of Human VEGFR1/Flt-1 by Western Blot Exogenous VEGF165 suppresses RASSF1A expression in normal epithelial and endothelial cells. Metastatic colon cancer cells (mCRC, (A) T84 and (B) Colo 205) were stimulated with VEGF165 as indicated before and cell metabolism was performed by MTT assay for 6 h (black dash), 24 h (green) and 48 h (pink). Immortalized benign protate ((C) RWPE1), human bronchial epithelial cells ((D) HBEpc), immortalized human breast epithelial cells ((E) MCF-10A), endothelial cells (F, EC) were stimulated with or without VEGF165 (12.5 and 25 ng/mL) for 24 h. Cell lysates were monitored by Western blot for p-VEGFR1, p-VEGFR2, RASSF1A, and GAPDH as indicated. Immunoblot was quantified by scanning densitometry and normalized against GAPDH expression for RWPE1 (G), HBEpc (H), MCF 10A (I) and EC (lower panel of (F)). Results are from three independent experiments and statistical significance was determined using one way-ANOVA followed Bonferroni test. (* p < 0.05, ** p < 0.01, *** p < 0.001). Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/30744076), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Human VEGFR1/Flt-1 by Western Blot View Larger

Detection of Human VEGFR1/Flt-1 by Western Blot Exogenous VEGF165 suppresses RASSF1A expression in normal epithelial and endothelial cells. Metastatic colon cancer cells (mCRC, (A) T84 and (B) Colo 205) were stimulated with VEGF165 as indicated before and cell metabolism was performed by MTT assay for 6 h (black dash), 24 h (green) and 48 h (pink). Immortalized benign protate ((C) RWPE1), human bronchial epithelial cells ((D) HBEpc), immortalized human breast epithelial cells ((E) MCF-10A), endothelial cells (F, EC) were stimulated with or without VEGF165 (12.5 and 25 ng/mL) for 24 h. Cell lysates were monitored by Western blot for p-VEGFR1, p-VEGFR2, RASSF1A, and GAPDH as indicated. Immunoblot was quantified by scanning densitometry and normalized against GAPDH expression for RWPE1 (G), HBEpc (H), MCF 10A (I) and EC (lower panel of (F)). Results are from three independent experiments and statistical significance was determined using one way-ANOVA followed Bonferroni test. (* p < 0.05, ** p < 0.01, *** p < 0.001). Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/30744076), licensed under a CC-BY license. Not internally tested by R&D Systems.

Flow Cytometry View Larger

Detection of VEGFR1/Flt-1 in HUVEC cells by Flow Cytometry HUVEC cells were stained with Goat Anti-Human VEGFR1/Flt-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF321, filled histogram) or isotype control antibody (Catalog # AB-108-C, open histogram) followed by Allophycocyanin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0108). View our protocol for Staining Membrane-associated Proteins.

Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Loading...
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: VEGFR1/Flt-1

Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) is a receptor tyrosine kinase that is expressed primarily on endothelial cells and plays a role in vasculogenesis and angiogenesis. A soluble variant of VEGFR1 was also reported to bind VEGF and PlGF with high affinity and function as a potent VEGF antagonist.

Long Name
Vascular Endothelial Growth Factor Receptor 1
Entrez Gene IDs
2321 (Human); 14254 (Mouse)
Alternate Names
EC 2.7.10; EC 2.7.10.1; FLT; FLT1; Flt-1; Fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascularpermeability factor receptor); FRT; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor 1; Vascular permeability factor receptor; VEGF R1; VEGFR1; VEGFR-1

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Citations for Human VEGFR1/Flt-1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

73 Citations: Showing 1 - 10
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  1. Expression of VEGF, its receptors, and HIF-1 alpha in Dupuytren’s disease
    Authors: Lukas A Holzer, Andrej Cör, Gerhard Pfandlsteiner, Gerold Holzer
    Acta Orthopaedica
  2. Histopathological investigation of glioblastomas resected under bevacizumab treatment
    Authors: Ryota Tamura, Toshihide Tanaka, Keisuke Miyake, Yusuke Tabei, Kentaro Ohara, Oltea Sampetrean et al.
    Oncotarget
  3. Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting vascular endothelial growth factor receptor 2–mediated angiogenesis
    Authors: Sarita Saraswati, Pawan K Kanaujia, Shakti Kumar, Ranjeet Kumar, Abdulqader A Alhaider
    Molecular Cancer
  4. Placental sFLT1 is associated with complement activation and syncytiotrophoblast damage in preeclampsia
    Authors: Ai-ris Yonekura Yonekura Collier, Zsuzsanna Zsengeller, Elizabeth Pernicone, Saira Salahuddin, Eliyahu V. Khankin, S. Ananth Karumanchi
    Hypertension in Pregnancy
  5. Low-Dose Recombinant Adeno-Associated Virus-Mediated Inhibition of Vascular Endothelial Growth Factor Can Treat Neovascular Pathologies Without Inducing Retinal Vasculitis
    Authors: Shun-Yun Cheng, Yongwen Luo, Anneliese Malachi, Jihye Ko, Qin Su, Jun Xie et al.
    Human Gene Therapy
  6. A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain
    Authors: Deepitha Selvaraj, Vijayan Gangadharan, Christoph W. Michalski, Martina Kurejova, Sebastian Stösser, Kshitij Srivastava et al.
    Cancer Cell
  7. Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia
    Authors: L Chen, E Okeke, D Ayalew, D Wang, L Shahid, AO Dokun
    Exp. Biol. Med. (Maywood), 2017-06-21;0(0):1535370217716.
  8. FKBPL and SIRT-1 Are Downregulated by Diabetes in Pregnancy Impacting on Angiogenesis and Endothelial Function
    Authors: Abdelrahim Alqudah, Kelly-Ann Eastwood, Djurdja Jerotic, Naomi Todd, Denise Hoch, Ross McNally et al.
    Front Endocrinol (Lausanne)
  9. Circulating Levels of sFlt1 Splice Variants as Predictive Markers for the Development of Preeclampsia
    Authors: Colby A. Souders, Sharon E. Maynard, Jing Yan, Yang Wang, Naomi K. Boatright, Jessica Sedan et al.
    International Journal of Molecular Sciences
  10. Modulation of cerebral endothelial cell function by TGF-beta in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition
    Authors: Shanmugarajan Krishnan, Emese Szabo, Isabel Burghardt, Karl Frei, Ghazaleh Tabatabai, Michael Weller
    Oncotarget
  11. Alterations of the tumor microenvironment in glioblastoma following radiation and temozolomide with or without bevacizumab
    Authors: Ryota Tamura, Toshihide Tanaka, Yukina Morimoto, Yuki Kuranari, Yohei Yamamoto, Jun Takei et al.
    Annals of Translational Medicine
  12. Analysis of Tumor Angiogenesis and Immune Microenvironment in Non-Functional Pituitary Endocrine Tumors
    Authors: Mizuto Sato, Ryota Tamura, Haruka Tamura, Taro Mase, Kenzo Kosugi, Yukina Morimoto et al.
    Journal of Clinical Medicine
  13. VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis
    Authors: Gareth W. Fearnley, Gina A. Smith, Izma Abdul-Zani, Nadira Yuldasheva, Nadeem A. Mughal, Shervanthi Homer-Vanniasinkam et al.
    Biology Open
  14. Expression of the soluble vascular endothelial growth factor receptor-1 in cutaneous melanoma: role in tumour progression
    Authors: F. Ruffini, C.M. Failla, A. Orecchia, M.R. Bani, A.S. Dorio, C. Fortes et al.
    British Journal of Dermatology
  15. Density of human bone marrow stromal cells regulates commitment to vascular lineages
    Authors: Jemima L. Whyte, Stephen G. Ball, C. Adrian Shuttleworth, Keith Brennan, Cay M. Kielty
    Stem Cell Research
  16. Placenta growth factor and neuropilin-1 collaborate in promoting melanoma aggressiveness
    Authors: ELENA PAGANI, FEDERICA RUFFINI, GIAN CARLO ANTONINI Antonini Cappellini, ALESSANDRO SCOPPOLA, CRISTINA FORTES, PAOLO MARCHETTI et al.
    International Journal of Oncology
  17. Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1
    Authors: Chao Li, Nandita S Raikwar, Mark K Santillan, Donna A Santillan, Christie P. Thomas
    Placenta
  18. Lysosomal Pathways and Autophagy Distinctively Control Endothelial Cell Behavior to Affect Tumor Vasculature
    Authors: Marco B. Schaaf, Diede Houbaert, Odeta Meçe, San Kit To, Maarten Ganne, Hannelore Maes et al.
    Frontiers in Oncology
  19. From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway
    Authors: Ricardo J. Giordano, Marina Cardó-Vila, Ahmad Salameh, Cristiane D. Anobom, Benjamin D. Zeitlin, David H. Hawke et al.
    Proceedings of the National Academy of Sciences
  20. MIF Increases sFLT1 Expression in Early Uncomplicated Pregnancy and Preeclampsia
    Authors: Yong, Q;Dijkstra, KL;van der Keur, C;Bruijn, JA;Eikmans, M;Baelde, HJ;
    International journal of molecular sciences
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  21. sFlt-1-enriched exosomes induced endothelial cell dysfunction and a preeclampsia-like phenotype in mice
    Authors: X Huang, L Jia, Y Jia, X Xu, R Wang, M Wei, H Li, H Peng, Y Wei, Q He, K Wang
    Cytokine, 2023-04-14;166(0):156190.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  22. Interaction between PD-L1 and soluble VEGFR1 in glioblastoma-educated macrophages
    Authors: X Liu, Z Li, J Sun, Z Zhang, W Li
    BMC Cancer, 2023-03-20;23(1):259.
    Species: Human
    Sample Types: Whole Cells
    Applications: Functional Assay
  23. Design, construction and in vivo functional assessment of a hinge truncated sFLT01
    Authors: F Zakeri, H Latifi-Nav, ZS Soheili, M Sadeghi, SS Arab, S Samiei, ER Pirmardan, S Taghizadeh, H Ahmadieh, A Hafezi-Mog
    Gene Therapy, 2022-09-16;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  24. Oviductal Oxygen Homeostasis in Patients with Uterine Myoma: Correlation between Hypoxia and Telocytes
    Authors: A Wrona, V Aleksandro, T Bereza, P Basta, A Gil, M Ulatowska-, M Mazur-Lask, K Pity?ski, K Gil
    International Journal of Molecular Sciences, 2022-05-31;23(11):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  25. Single-nucleus transcriptome analysis reveals disease- and regeneration-associated endothelial cells in white matter vascular dementia
    Authors: DN Mitroi, M Tian, R Kawaguchi, WE Lowry, ST Carmichael
    Journal of Cellular and Molecular Medicine, 2022-05-11;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  26. Salvianolic acid B and ferulic acid synergistically promote angiogenesis in HUVECs and zebrafish via regulating VEGF signaling
    Authors: J Chen, Y Wang, S Wang, X Zhao, L Zhao, Y Wang
    Journal of ethnopharmacology, 2021-09-29;0(0):114667.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  27. Oviductal Telocytes in Patients with Uterine Myoma
    Authors: V Aleksandro, A Wrona, T Bereza, K Pity?ski, K Gil
    Biomedicines, 2021-08-20;9(8):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  28. Molecular investigation of brain tumors progressing during pregnancy or postpartum period: the association between tumor type, their receptors, and the timing of presentation
    Authors: S Ichimura, K Ohara, M Kono, K Mizutani, Y Kitamura, I Saga, R Kanai, T Akiyama, M Toda, M Kohno, K Yoshida, H Sasaki
    Clinical neurology and neurosurgery, 2021-06-01;207(0):106720.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  29. Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF?1&alpha and VEGF expression
    Authors: D Dong, Y Fu, F Chen, J Zhang, H Jia, J Li, H Wang, J Wen
    Mol Med Rep, 2020-11-20;23(1):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  30. Atypical chemokine receptor ACKR3/CXCR7 controls postnatal vasculogenesis and arterial specification by mesenchymal stem cells via Notch signaling
    Authors: ST Wei, YC Huang, ML Hsieh, YJ Lin, WC Shyu, HC Chen, CH Hsieh
    Cell Death Dis, 2020-05-04;11(5):307.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  31. BMP9 signaling promotes the normalization of tumor blood vessels
    Authors: C Viallard, C Audiger, N Popovic, N Akla, K Lanthier, I Legault-Na, H Melichar, S Costantino, S Lesage, B Larrivée
    Oncogene, 2020-02-10;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  32. Soluble fms-Like Tyrosine Kinase 1 Localization in Renal Biopsies of CKD
    Authors: ZK Zsengellér, A Lo, M Tavasoli, E Pernicone, SA Karumanchi, S Rosen
    Kidney Int Rep, 2019-08-14;4(12):1735-1741.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr, IHC-P
  33. Human Umbilical Tissue-Derived Cells Secrete Soluble VEGFR1 and Inhibit Choroidal Neovascularization
    Authors: J Cao, R Yang, TE Smith, S Evans, GW McCollum, SC Pomerantz, T Petley, IR Harris, JS Penn
    Mol Ther Methods Clin Dev, 2019-05-22;14(0):37-46.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Western Blot
  34. MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells
    Authors: KY Han, JH Chang, DT Azar
    Invest. Ophthalmol. Vis. Sci., 2019-05-01;60(6):2321-2329.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  35. Intravitreal Injection of AAV Expressing Soluble VEGF Receptor-1 Variant Induces Anti-VEGF Activity and Suppresses Choroidal Neovascularization
    Authors: SHS Lee, HJ Kim, OK Shin, JS Choi, J Kim, YH Cho, J Ha, TK Park, JY Lee, K Park, H Lee
    Invest. Ophthalmol. Vis. Sci., 2018-11-01;59(13):5398-5407.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  36. VEGF vascularization pathway in human intervertebral disc does not change during the disc degeneration process
    Authors: S Capossela, A Bertolo, K Gunasekera, T Pötzel, M Baur, JV Stoyanov
    BMC Res Notes, 2018-05-22;11(1):333.
    Species: Bovine, Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  37. Villous explants from preeclamptic placentas induce sFlt1 in PBMCs: An ex vivo co-culture study
    Authors: SK Gonzales, M Badell, H Cottrell, B Rimawi, V Deepak, N Sidell, A Rajakumar
    Pregnancy Hypertens, 2018-02-25;12(0):40-46.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  38. Ferrochelatase is a therapeutic target for ocular neovascularization
    Authors: HD Basavaraja, RS Sulaiman, X Qi, T Shetty, S Sheik Pran, KL Sishtla, B Lee, J Quigley, S Alkhairy, CM Briggs, K Gupta, B Tang, M Shadmand, MB Grant, ME Boulton, SY Seo, TW Corson
    EMBO Mol Med, 2017-06-01;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  39. Placental soluble fms-like tyrosine kinase expression in small for gestational age infants and risk for adverse outcomes
    Authors: M Spiel, S Salahuddin, E Pernicone, Z Zsengeller, A Wang, AM Modest, SA Karumanchi, JL Hecht
    Placenta, 2017-02-10;52(0):10-16.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  40. Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells.
    Authors: Alessio D'alessio, Gabriella Proietti, Gina Lama, Filippo Biamonte, Libero Lauriola, Umberto Moscato, Angelo Vescovi, Annunziato Mangiola, Cristiana Angelucci, Gigliola Sica
    Oncotarget, 2016-11-29;0(0):1949-2553.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  41. Hypoxia Differentially Regulates Arterial and Venous Smooth Muscle Cell Migration.
    Authors: Chanakira A, Kir D, Barke R, Santilli S, Ramakrishnan S, Roy S
    PLoS ONE, 2015-09-18;10(9):e0138587.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  42. The effect of vascular endothelial growth factor on osteoclastogenesis in rheumatoid arthritis.
    Authors: Kim H, Kim K, Kim B, Cho M, Lee S
    PLoS ONE, 2015-04-20;10(4):e0124909.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  43. Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice.
    Authors: Szalai G, Romero R, Chaiworapongsa T, Xu Y, Wang B, Ahn H, Xu Z, Chiang P, Sundell B, Wang R, Jiang Y, Plazyo O, Olive M, Tarca A, Dong Z, Qureshi F, Papp Z, Hassan S, Hernandez-Andrade E, Than N
    PLoS ONE, 2015-04-10;10(4):e0119547.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  44. Merkel cell carcinoma expresses vasculogenic mimicry: demonstration in patients and experimental manipulation in xenografts.
    Authors: Lezcano C, Kleffel S, Lee N, Larson A, Zhan Q, DoRosario A, Wang L, Schatton T, Murphy G
    Lab Invest, 2014-08-11;94(10):1092-102.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  45. Elastase induces lung epithelial cell autophagy through placental growth factor: a new insight of emphysema pathogenesis.
    Authors: Hou H, Cheng S, Chung K, Kuo M, Yeh C, Chang B, Lu H, Wang H, Yu C
    Autophagy, 2014-06-25;10(9):1509-21.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  46. Sustained delivery of VEGF maintains innervation and promotes reperfusion in ischemic skeletal muscles via NGF/GDNF signaling.
    Authors: Shvartsman, Dmitry, Storrie-White, Hannah, Lee, Kangwon, Kearney, Cathal, Brudno, Yevgeny, Ho, Nhi, Cezar, Christin, McCann, Corey, Anderson, Erin, Koullias, John, Tapia, Juan Car, Vandenburgh, Herman, Lichtman, Jeff W, Mooney, David J
    Mol Ther, 2014-04-28;22(7):1243-53.
    Species: Human
    Sample Types: Whole Cells
    Applications: Functional Assay
  47. Melanoma spheroid formation involves laminin-associated vasculogenic mimicry.
    Authors: Larson A, Lee C, Lezcano C, Zhan Q, Huang J, Fischer A, Murphy G
    Am J Pathol, 2014-01-01;184(1):71-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  48. Pancreatic-carcinoma-cell-derived pro-angiogenic factors can induce endothelial-cell differentiation of a subset of circulating CD34+ progenitors.
    Authors: Vizio, Barbara, Biasi, Fiorella, Scirelli, Tiziana, Novarino, Anna, Prati, Adriana, Ciuffreda, Libero, Montrucchio, Giuseppe, Poli, Giuseppe, Bellone, Graziell
    J Transl Med, 2013-12-17;11(0):314.
    Species: Human
    Sample Types: Whole Cells
    Applications: Blocking
  49. Attenuation of VEGFR-2 expression by sFlt-1 and low oxygen in human placenta.
    Authors: Nevo, Ori, Lee, Dennis K, Caniggia, Isabella
    PLoS ONE, 2013-11-19;8(11):e81176.
    Species: Human
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: Neutralization, Western Blot
  50. Differential expression of Vegfr-2 and its soluble form in preeclampsia.
    Authors: Munaut C, Lorquet S, Pequeux C, Coulon C, Le Goarant J, Chantraine F, Noel A, Goffin F, Tsatsaris V, Subtil D, Foidart JM
    PLoS ONE, 2012-03-12;7(3):e33475.
    Species: Human
    Sample Types: Plasma, Whole Tissue
    Applications: IHC-P, Western Blot
  51. gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.
    Authors: Cai J, Chen Z, Ruan Q, Han S, Liu L, Qi X, Boye SL, Hauswirth WW, Grant MB, Boulton ME
    J. Biol. Chem., 2011-10-20;286(49):42514-23.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Proximity Ligation Assay (PLA)
  52. Glyceryl trinitrate inhibits hypoxia-induced release of soluble fms-like tyrosine kinase-1 and endoglin from placental tissues.
    Authors: Barsoum IB, Renaud SJ, Graham CH
    Am. J. Pathol., 2011-06-01;178(6):2888-96.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  53. Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGF-R2/PI3K/Akt.
    Authors: Byeon SH, Lee SC, Choi SH, Lee HK, Lee JH, Chu YK, Kwon OW
    Invest. Ophthalmol. Vis. Sci., 2009-10-15;51(2):1190-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC, Neutralization
  54. Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis.
    Authors: Lee HS, Myers A, Kim J
    Am. J. Respir. Crit. Care Med., 2009-09-17;180(11):1056-67.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: IHC, Neutralization
  55. Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
    Authors: Ball SG, Shuttleworth CA, Kielty CM
    J. Cell Biol., 2007-04-30;177(3):489-500.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  56. Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential.
    Authors: Cianfarani F, Zambruno G, Brogelli L, Sera F, Lacal PM, Pesce M, Capogrossi MC, Failla CM, Napolitano M, Odorisio T
    Am. J. Pathol., 2006-10-01;169(4):1167-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  57. Antagonists to human and mouse vascular endothelial growth factor receptor 2 generated by directed protein evolution in vitro.
    Authors: Getmanova EV, Chen Y, Bloom L, Gokemeijer J, Shamah S, Warikoo V, Wang J, Ling V, Sun L
    Chem. Biol., 2006-05-01;13(5):549-56.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  58. Skeletal site-specific characterization of orofacial and iliac crest human bone marrow stromal cells in same individuals.
    Authors: Akintoye SO, Lam T, Shi S, Brahim J, Collins MT, Robey PG
    Bone, 2006-01-03;38(6):758-68.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  59. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung.
    Authors: Asikainen TM, Schneider BK, Waleh NS, Clyman RI, Ho WB, Flippin LA, Gunzler V, White CW
    Proc. Natl. Acad. Sci. U.S.A., 2005-07-11;102(29):10212-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC, Neutralization
  60. PEDF derived from glial Muller cells: a possible regulator of retinal angiogenesis.
    Authors: Eichler W, Yafai Y, Keller T, Wiedemann P, Reichenbach A
    Exp. Cell Res., 2004-09-10;299(1):68-78.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  61. All three receptors for vascular endothelial growth factor (VEGF) are expressed on B-chronic lymphocytic leukemia (CLL) cells.
    Authors: Bairey O, Boycov O, Kaganovsky E, Zimra Y, Shaklai M, Rabizadeh E
    Leuk. Res., 2004-03-01;28(3):243-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  62. Proangiogenic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesis.
    Authors: Giuliani N, Colla S, Lazzaretti M, Sala R, Roti G, Mancini C, Bonomini S, Lunghi P, Hojden M, Genestreti G, Svaldi M, Coser P, Fattori PP, Sammarelli G, Gazzola GC, Almici C, Caramatti C, Mangoni L, Rizzoli V
    Blood, 2003-03-20;102(2):638-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  63. Identification of Cross Talk between FoxM1 and RASSF1A as a Therapeutic Target of Colon Cancer
    Authors: Thomas G. Blanchard, Steven J. Czinn, Vivekjyoti Banerjee, Neha Sharda, Andrea C. Bafford, Fahad Mubariz et al.
    Cancers (Basel)
  64. Thyroid Transcription Factor 1 Reprograms Angiogenic Activities of Secretome
    Authors: Lauren W. Wood, Nicole I. Cox, Cody A. Phelps, Shao-Chiang Lai, Arjun Poddar, Conover Talbot et al.
    Scientific Reports
  65. Transcriptionally Active Syncytial Aggregates in the Maternal Circulation May Contribute to Circulating Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia
    Authors: Augustine Rajakumar, Ana Sofia Cerdeira, Sarosh Rana, Zsuzsanna Zsengeller, Lia Edmunds, Arun Jeyabalan et al.
    Hypertension
  66. Angiogenic dysfunction in molar pregnancy
    Authors: David Kanter, Marshall D. Lindheimer, Eileen Wang, Romana G. Borromeo, Elizabeth Bousfield, S. Ananth Karumanchi et al.
    American Journal of Obstetrics and Gynecology
  67. Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity
    Authors: Kirsten R. Palmer, Tu’uhevaha J. Kaitu’u-Lino, Roxanne Hastie, Natalie J. Hannan, Louie Ye, Natalie Binder et al.
    Hypertension
  68. “Paradoxical” findings of tumor vascularity and oxygenation in recurrent glioblastomas refractory to bevacizumab
    Authors: Yohei Yamamoto, Ryota Tamura, Toshihide Tanaka, Kentaro Ohara, Yukina Tokuda, Keisuke Miyake et al.
    Oncotarget
  69. N-Terminal Cleavage and Release of the Ectodomain of Flt1 Is Mediated via ADAM10 and ADAM 17 and Regulated by VEGFR2 and the Flt1 Intracellular Domain
    Authors: Nandita S. Raikwar, Kang Z. Liu, Christie P. Thomas
    PLoS ONE
  70. Differential Effects of VEGFR-1 and VEGFR-2 Inhibition on Tumor Metastases Based on Host Organ Environment
    Authors: Yoon-Jin Lee, Daniel L. Karl, Ugwuji N. Maduekwe, Courtney Rothrock, Sandra Ryeom, Patricia A. D'Amore et al.
    Cancer Research
  71. Protein kinase C regulates FLT1 abundance and stimulates its cleavage in vascular endothelial cells with the release of a soluble PlGF/VEGF antagonist
    Authors: Nandita S. Raikwar, Kang Z. Liu, Christie P. Thomas
    Experimental Cell Research
  72. Targeting VEGFR1- and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy
    Authors: Wen Wen Xu, Bin Li, Alfred K Y Lam, Sai Wah Tsao, Simon Y K Law, Kwok Wah Chan et al.
    Oncotarget

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Human VEGFR1/Flt-1 Antibody
By Anonymous on 05/25/2024
Application: IHC Sample Tested: Embryonic retina Species: Mouse
Immunohistochemistry Human VEGFR1/Flt-1 Antibody AF321
Human VEGFR1/Flt-1 Antibody
By Anonymous on 03/24/2021
Application: WB Sample Tested: HUVEC human umbilical vein endothelial cells Species: Human
Western Blot Human VEGFR1/Flt-1 Antibody AF321
Human VEGFR1/Flt-1 Antibody
By Anonymous on 03/24/2021
Application: Immunocytochemistry/Immunofluorescence Sample Tested: HUVEC human umbilical vein endothelial cells Species: Human
Immunocytochemistry/Immunofluorescence Human VEGFR1/Flt-1 Antibody AF321
Human VEGF R1/Flt-1 Antibody
By Tamar Licht on 08/08/2018
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Embryonic brain Species: Mouse
Immunocytochemistry/Immunofluorescence Human VEGF R1/Flt-1 Antibody AF321
Human VEGF R1/Flt-1 Antibody
By Anonymous on 07/08/2016
Application: Immunocytochemistry/Immunofluorescence Sample Tested: CT26 mouse colorectal cancer cell line,Human liver cancer cell line Species: Human