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Human VEGF-C Antibody

Catalog #: MAB752
2 Citations Datasheet
Catalog # Availability Size / Price Qty
MAB752-SP
MAB752-100
MAB752-500
Human VEGF‑C ELISA Standard Curve.
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Product Details
Citations (2)
FAQs
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human VEGF-C Antibody Summary

Species Reactivity
Human
Specificity
Detects human VEGF-C in direct ELISAs and Western blots. In direct ELISAs, this antibody does not cross-react with recombinant human (rh) PDGF‑AA, rhPDGF‑BB, rhPlGF, rhVEGF165, rhVEGF206, rhVEGF-B186, or rhVEGF-D.
Source
Monoclonal Mouse IgG2B Clone # 193208
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human VEGF-C
Thr103-Arg227 (Cys156Ser)
Accession # Q6FH59
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human VEGF-C (Catalog # 2179-VC)
ELISA

This antibody functions as an ELISA capture antibody when paired with Goat Anti-Human VEGF‑C Antigen Affinity-purified Polyclonal Antibody (Catalog # AF752).

This product is intended for assay development on various assay platforms requiring antibody pairs. We recommend the Human VEGF-C DuoSet ELISA Kit (Catalog # DY752B) for convenient development of a sandwich ELISA or the Human VEGF-C Quantikine ELISA Kit (Catalog # DVEC00) for  a complete optimized ELISA.

 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

ELISA View Larger

Human VEGF‑C ELISA Standard Curve. Recombinant Human VEGF‑C protein was serially diluted 2-fold and captured by Mouse Anti-Human VEGF‑C Monoclonal Antibody (Catalog # MAB752) coated on a Clear Polystyrene Microplate (DY990). Goat Anti-Human VEGF‑C Antigen Affinity-purified Polyclonal Antibody (AF752) was biotinylated and incubated with the protein captured on the plate. Detection of the standard curve was achieved by incubating Streptavidin-HRP (DY998) followed by Substrate Solution (DY999) and stopping the enzymatic reaction with Stop Solution (DY994).

Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: VEGF-C

Vascular Endothelial Growth Factor C (VEGF-C) is a member of the VEGF family of secreted growth factors. The VHD form homodimers after proteolytic removal of the N- and C-terminal pro regions. VEGF-C promotes angiogenesis and lymphangiogenesis through interactions with VEGF R2 and VEGF R3.

Long Name
Vascular Endothelial Growth Factor C
Entrez Gene IDs
7424 (Human); 22341 (Mouse)
Alternate Names
Flt4 ligand; Flt4-L; vascular endothelial growth factor C; Vascular endothelial growth factor-related protein; VEGFC; VEGF-C; VRPFLT4 ligand DHM

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Citations for Human VEGF-C Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Intrathecal B Cells in MS Have Significantly Greater Lymphangiogenic Potential Compared to B Cells Derived From Non-MS Subjects
    Authors: Jason Stein, Quangang Xu, Kayla C. Jackson, Elena Romm, Simone C. Wuest, Peter Kosa et al.
    Frontiers in Neurology
  2. Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway.
    Authors: Chien MH, Ku CC, Johansson G, Chen MW, Hsiao M, Su JL, Inoue H, Hua KT, Wei LH, Kuo ML
    Carcinogenesis, 2009-12-01;30(12):2005-13.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P

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