Human TREM-1 PE-conjugated Antibody
Human TREM-1 PE-conjugated Antibody Summary
Ala21-Asn205
Accession # Q9NP99
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of TREM‑1 in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Mouse Anti-Human TREM-1 PE-conjugated Monoclonal Antibody (Catalog # FAB1278P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of TREM‑1 in THP-1 Human Cell Line by Flow Cytometry THP-1 human acute monocytic leukemia cell line was stained with Mouse Anti-Human TREM-1 PE-conjugated Monoclonal Antibody (Catalog # FAB1278P, filled histogram) or isotype control antibody (IC002P, open histogram). Staining was performed using our Staining Membrane-associated Proteins protocol.
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TREM-1 Specificity is Shown by Flow Cytometry in Knockout Cell Line. TREM-1 knockout THP-1 human acute monocytic leukemia cell line was stained with Mouse Anti-Human TREM-1 PE-conjugated Monoclonal Antibody (Catalog # FAB1278P, filled histogram) or isotype control antibody (IC002P,open histogram). No staining in the TREM-1 knockout THP-1 cell line was observed. Staining was performed using our Staining Membrane-associated Proteins protocol.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TREM-1
TREM-1 (Triggering Receptor Expressed on Myeloid cells) is a type I transmembrane protein having a single Ig-like domain. It associates with the adapter protein, DAP12, to deliver an activating signal. Several other TREM family members have been reported that are structurally similar but share less than 30% amino acid identity. TREM-1 is expressed on blood neutrophils and a subset of monocytes, and expression is up-regulated by bacterial LPS. The natural ligand for TREM-1 has not been identified. However, engagement of TREM-1 with an agonist monoclonal antibody leads to expression of IL-8, MCP-1, and TNF-alpha, suggesting that this receptor plays an important role in inflammatory responses. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with LPS-induced shock. Blockade of TREM-1 with a TREM-1/Fc fusion protein protected mice against LPS-induced shock. Human and mouse TREM-1 share approximately 42% amino acid sequence homology (1-3).
- Bouchon, A. (2000) J. Immunol. 164:4991.
- Bouchon, A. (2001) Nature 410:1103.
- Nathan, C. and A. Ding (2001) Nature Med. 7:530.
Product Datasheets
Citations for Human TREM-1 PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity
Authors: PV da Silva-N, JCS de Carvalh, VE Pimentel, MM Pérez, DM Toro, TFC Fraga-Silv, CA Fuzo, CNS Oliveira, LC Rodrigues, JGM Argolo, I Carmona-Ga, NT Neto, COS Souza, TM Fernandes, VAF Bastos, AM Degiovani, LF Constant, FM Ostini, MR Feitosa, RS Parra, FC Vilar, GG Gaspar, JJR da Rocha, O Feres, FG Frantz, RF Gerlach, SR Maruyama, EMS Russo, AL Viana, APM Fernandes, IKFM Santos, VLD Bonato, AL Boechat, A Malheiro, RT Sadikot, M Dias-Baruf, CRB Cardoso, LH Faccioli, CA Sorgi, On Behalf
Viruses, 2021-12-15;13(12):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
TREM-1 and TREM-2 Expression on Blood Monocytes Could Help Predict Survival in High-Grade Glioma Patients
Authors: K Kluckova, J Kozak, K Szaboova, B Rychly, M Svajdler, M Suchankova, E Tibenska, B Filova, J Steno, V Matejcik, M Homolova, M Bucova
Mediators Inflamm., 2020-07-01;2020(0):1798147.
Species: Human
Sample Types: Plasma, Whole Blood
Applications: Flow Cytometry -
TREM-1 and TREM-2 Expression on CD14+ Cells in Bronchoalveolar Lavage Fluid in Pulmonary Sarcoidosis and Hypersensitivity Pneumonitis in the Context of T Cell Immune Response
Authors: M Suchankova, J Urban, M Ganovska, E Tibenska, K Szaboova, E Tedlova, F Sandor, I Majer, M Bobovcak, I Jonner, B Konig, M Bucova
Mediators Inflamm., 2020-05-14;2020(0):9501617.
Species: Human
Sample Types: Bronchoalveolar lavage fluid
Applications: Flow Cytometry -
HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells
Authors: J Hyun, RS McMahon, AL Lang, JS Edwards, AD Badilla, ME Greene, GW Stone, S Pallikkuth, M Stevenson, DM Dykxhoorn, S Kottilil, S Pahwa, E Thomas
PLoS Pathog., 2019-07-01;15(7):e1007883.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Activation and Regulation of Blood V?2 T Cells Are Amplified by TREM-1during Active Pulmonary Tuberculosis
Authors: Y Wu, YM Fang, L Ding, X Liu, NM Francisco, J Wen, C Liao, Z Ma, Z Li, M Li, S Ming, T Liu, M Zhang, M Wu, M Jacobs, S Gong, X Huang
J. Immunol., 2018-02-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Urine TREM-1 as a marker of urinary tract infection in children
Authors: E Sierra-Dia, A Bravo Cuél, PC Ortiz Laza, M García Gut, HF Georgina, R Anaya Prad
J. Int. Med. Res., 2017-04-02;45(2):631-638.
Species: Human
Sample Types: Urine
Applications: Flow Cytometry -
TREM-1low is a novel characteristic for tumor-associated macrophages in lung cancer
Oncotarget, 2016-06-28;7(26):40508-40517.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Differential pattern of cell-surface and soluble TREM-1 between sepsis and SIRS.
Cytokine, 2012-10-06;61(1):112-7.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Role of MMPs in orchestrating inflammatory response in human monocytes via a TREM-1-PI3K-NF-kappaB pathway.
J. Cell. Sci., 2012-03-29;91(6):933-45.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.
Authors: Bosco MC, Pierobon D, Blengio F, Raggi F, Vanni C, Gattorno M, Eva A, Novelli F, Cappello P, Giovarelli M, Varesio L
Blood, 2010-12-10;117(9):2625-39.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4.
Authors: Fortin CF, Lesur O, Fulop T
Int. Immunol., 2006-11-10;19(1):41-50.
Species: Human
Sample Types: Whole Cells
Applications: ICC
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